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• W2024581621 abstract "Wistar rats were administered M-protein fraction (MP) of group A type 12 hemolytic streptococci or rabbit anti-MP serum (AMPS) on day 9 of gestation. The incidence of malformations was 11.8% when 9 mg/kg of MP was administered and 12.0% when 9 ml/kg of AMPS was injected. The main malformations observed in both groups were ventricular septal defect, microphthalmia, anophthalmia, and hydrocephaly. Light and electron microscopic studies revealed no myocarditis nor endocarditis in either the maternal or fetal heart. Fluorescent antibody technique demonstrated no localization of anti-MP antibodies on the maternal heart. The results suggest that MP and AMPS are slightly teratogenic in the rat, and that the teratogenesis is not caused by an autoimmune mechanism." @default.
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• W2024581621 date "1984-12-01" @default.
• W2024581621 modified "2023-09-26" @default.
• W2024581621 title "The Effects of M-protein Fraction of Hemolytic Streptococci on Embryonic Development in the Rat" @default.
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• W2024581621 doi "https://doi.org/10.1111/j.1741-4520.1984.tb00933.x" @default.
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