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• W2024582697 abstract "A novel series of 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines has been synthesized and evaluated as novel nicotinic acetylcholine receptor ligands. Changing the pyrrolidine stereochemistry and N-substitution pattern afforded analogs with Ki values ranging from 2.7 to 97 nM. Rubidium efflux studies revealed that these compounds had intrinsic activities ranging from 9–58% that of nicotine in the IMR-32 cell line and 6–81% in the K177 cell line. The N(Me)-2(S) analog 3a demonstrated good selectivity in the K177 cell line (α4β2 receptor) versus the IMR-32 cells (α3βx receptor) and TE 671 cells (α1 neuromuscular receptor), and was a partial agonist with an EC50 value of 141 nM in dopamine release assay using rat striatal slices." @default.
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• W2024582697 date "1997-11-01" @default.
• W2024582697 modified "2023-09-23" @default.
• W2024582697 title "Novel 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands" @default.
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• W2024582697 doi "https://doi.org/10.1016/s0960-894x(97)10080-4" @default.
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