Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024583092> ?p ?o ?g. }
- W2024583092 endingPage "572" @default.
- W2024583092 startingPage "565" @default.
- W2024583092 abstract "Trivalent chromium (Cr(3+)) is known to improve glucose homeostasis. Cr(3+) has been shown to improve plasma membrane-based aspects of glucose transporter GLUT4 regulation and increase activity of the cellular energy sensor 5' AMP-activated protein kinase (AMPK). However, the mechanism(s) by which Cr(3+) improves insulin responsiveness and whether AMPK mediates this action is not known. In this study we tested if Cr(3+) protected against physiological hyperinsulinemia-induced plasma membrane cholesterol accumulation, cortical filamentous actin (F-actin) loss and insulin resistance in L6 skeletal muscle myotubes. In addition, we performed mechanistic studies to test our hypothesis that AMPK mediates the effects of Cr(3+) on GLUT4 and glucose transport regulation. Hyperinsulinemia-induced insulin-resistant L6 myotubes displayed excess membrane cholesterol and diminished cortical F-actin essential for effective glucose transport regulation. These membrane and cytoskeletal abnormalities were associated with defects in insulin-stimulated GLUT4 translocation and glucose transport. Supplementing the culture medium with pharmacologically relevant doses of Cr(3+) in the picolinate form (CrPic) protected against membrane cholesterol accumulation, F-actin loss, GLUT4 dysregulation and glucose transport dysfunction. Insulin signaling was neither impaired by hyperinsulinemic conditions nor enhanced by CrPic, whereas CrPic increased AMPK signaling. Mechanistically, siRNA-mediated depletion of AMPK abolished the protective effects of CrPic against GLUT4 and glucose transport dysregulation. Together these findings suggest that the micronutrient Cr(3+), via increasing AMPK activity, positively impacts skeletal muscle cell insulin sensitivity and glucose transport regulation." @default.
- W2024583092 created "2016-06-24" @default.
- W2024583092 creator A5009269808 @default.
- W2024583092 creator A5009513439 @default.
- W2024583092 creator A5042889049 @default.
- W2024583092 creator A5044182566 @default.
- W2024583092 creator A5044973559 @default.
- W2024583092 creator A5056763676 @default.
- W2024583092 date "2014-05-01" @default.
- W2024583092 modified "2023-10-14" @default.
- W2024583092 title "Chromium enhances insulin responsiveness via AMPK" @default.
- W2024583092 cites W1964268690 @default.
- W2024583092 cites W1968375269 @default.
- W2024583092 cites W1976023335 @default.
- W2024583092 cites W1980676792 @default.
- W2024583092 cites W1981755538 @default.
- W2024583092 cites W1983180942 @default.
- W2024583092 cites W1988895526 @default.
- W2024583092 cites W1991113786 @default.
- W2024583092 cites W1993830514 @default.
- W2024583092 cites W1998023135 @default.
- W2024583092 cites W2002693498 @default.
- W2024583092 cites W2014742651 @default.
- W2024583092 cites W2016264464 @default.
- W2024583092 cites W2017760793 @default.
- W2024583092 cites W2023581351 @default.
- W2024583092 cites W2023873099 @default.
- W2024583092 cites W2026334927 @default.
- W2024583092 cites W2030177383 @default.
- W2024583092 cites W2036227669 @default.
- W2024583092 cites W2043996770 @default.
- W2024583092 cites W2049489390 @default.
- W2024583092 cites W2051033370 @default.
- W2024583092 cites W2052902018 @default.
- W2024583092 cites W2058035657 @default.
- W2024583092 cites W2074653337 @default.
- W2024583092 cites W2078903832 @default.
- W2024583092 cites W2084513141 @default.
- W2024583092 cites W2085336267 @default.
- W2024583092 cites W2085536836 @default.
- W2024583092 cites W2086439115 @default.
- W2024583092 cites W2089635824 @default.
- W2024583092 cites W2091510428 @default.
- W2024583092 cites W2097363242 @default.
- W2024583092 cites W2110898469 @default.
- W2024583092 cites W2112401383 @default.
- W2024583092 cites W2113637996 @default.
- W2024583092 cites W2117680364 @default.
- W2024583092 cites W2119581987 @default.
- W2024583092 cites W2121098010 @default.
- W2024583092 cites W2123947478 @default.
- W2024583092 cites W2131717657 @default.
- W2024583092 cites W2134141508 @default.
- W2024583092 cites W2136626081 @default.
- W2024583092 cites W2140442640 @default.
- W2024583092 cites W2141561531 @default.
- W2024583092 cites W2142688280 @default.
- W2024583092 cites W2151145183 @default.
- W2024583092 cites W2152840919 @default.
- W2024583092 cites W2153150692 @default.
- W2024583092 cites W2156161389 @default.
- W2024583092 cites W2162788755 @default.
- W2024583092 cites W2167698452 @default.
- W2024583092 cites W2189412469 @default.
- W2024583092 doi "https://doi.org/10.1016/j.jnutbio.2014.01.007" @default.
- W2024583092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4030743" @default.
- W2024583092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24725432" @default.
- W2024583092 hasPublicationYear "2014" @default.
- W2024583092 type Work @default.
- W2024583092 sameAs 2024583092 @default.
- W2024583092 citedByCount "47" @default.
- W2024583092 countsByYear W20245830922014 @default.
- W2024583092 countsByYear W20245830922015 @default.
- W2024583092 countsByYear W20245830922016 @default.
- W2024583092 countsByYear W20245830922017 @default.
- W2024583092 countsByYear W20245830922018 @default.
- W2024583092 countsByYear W20245830922019 @default.
- W2024583092 countsByYear W20245830922020 @default.
- W2024583092 countsByYear W20245830922021 @default.
- W2024583092 countsByYear W20245830922022 @default.
- W2024583092 countsByYear W20245830922023 @default.
- W2024583092 crossrefType "journal-article" @default.
- W2024583092 hasAuthorship W2024583092A5009269808 @default.
- W2024583092 hasAuthorship W2024583092A5009513439 @default.
- W2024583092 hasAuthorship W2024583092A5042889049 @default.
- W2024583092 hasAuthorship W2024583092A5044182566 @default.
- W2024583092 hasAuthorship W2024583092A5044973559 @default.
- W2024583092 hasAuthorship W2024583092A5056763676 @default.
- W2024583092 hasBestOaLocation W20245830922 @default.
- W2024583092 hasConcept C126322002 @default.
- W2024583092 hasConcept C134018914 @default.
- W2024583092 hasConcept C142669718 @default.
- W2024583092 hasConcept C1491633281 @default.
- W2024583092 hasConcept C161573976 @default.
- W2024583092 hasConcept C184235292 @default.
- W2024583092 hasConcept C185592680 @default.
- W2024583092 hasConcept C2776188179 @default.
- W2024583092 hasConcept C2776780712 @default.