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- W2024585166 abstract "The postischemic infusion of ATP-MgCl2 is known to enhance recovery from acute renal failure. Since both ATP and MgCl2 are vasoactive compounds and increase renal blood flow (RBF), the hemodynamic effects of this complex were determined by treating animals with either dopamine (15 μg/kg), ATP-MgCl2 (25 μmoles) or normal saline (NS) after 45 min of renal ischemia. Inulin clearance (Cin) and renal blood flow (electromagnetic flow probe) were determined at 2 hrs and Cin and recovery of microinjected inulin (InR%) were evaluated 24 hrs after the injury. At 2 hrs the infusion of dopamine resulted in a level of RBF (1.70±0.09 ml/min/100gBW/kidney) and Cin (400±44 μl/min/100gBW) that was similar to that in the ATP-MgCl2 rats (1.73±0.27 RBF, 404±38 Cin and significantly (P<0.01) greater than NS rats (0.80±0.04 RBF, 78±19 Cin; P<0.01). However, by 24 hrs the Cin in dopamine animals had not continued to improve (460±25) and was similar to that in NS animals (388±40). In contrast, Cin in ATP-MgCl2 animals showed sustained and accelerated recovery (676±28; P<0.01). These differences resulted from improved integrity of the tubular epithelium as reflected by diminished backleak: InR 92±3% ATP-MgCl2; 45±5% dopamine; P<0.01). This study demonstrates that the initial hemodynamic effect of ATP-MgCl2 produces some improvement in Cin but the sustained salutary effect of this compound is related to the repair of sublethally injured tubular cells and restoration of cellular metabolism, which we have previously documented." @default.
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- W2024585166 date "1984-04-01" @default.
- W2024585166 modified "2023-10-06" @default.
- W2024585166 title "HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2" @default.
- W2024585166 doi "https://doi.org/10.1203/00006450-198404001-01613" @default.
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