FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024586196> ?p ?o ?g. }

• W2024586196 endingPage "908" @default.
• W2024586196 startingPage "901" @default.
• W2024586196 abstract "Abstract Inflammation is associated with modification of the extracellular environment, changes in cytokine expression, and the accumulation of immune cells. Such modifications create ligands that support SR-A-mediated macrophage adhesion and retention. This may be particularly important in settings, such as atherosclerosis and diabetes, as modified lipoproteins and gluc-collagen are ligands for SR-A. SR-A-mediated adhesion requires the PLA2-dependent generation of AA and its metabolism by 12/15 LOX. In contrast, the inhibition of the COX-dependent conversion of AA to PG had no effect on SR-A-mediated adhesion. In this study, macrophages were isolated from SR-A+/+ and SR-A−/− mice and plated on gluc-collagen to test the hypothesis that COX-derived PGs are produced during SR-A-mediated adhesion and regulate macrophage function. SR-A-mediated binding to gluc-collagen induced a rapid but transient increase in PG production, which required the activation of PLA2 and Src kinase but not PI3K. SR-A+/+ macrophages cultured on gluc-collagen for 24 h secreted a similar amount of TNF-α and 2.5-fold more IL-10 than SR-A−/− macrophages. The inhibition of COX substantially increased TNF-α production but reduced IL-10 levels in SR-A+/+ macrophages. These effects of COX inhibition were reversed by exogenous PGE2 and mimicked by specific antagonism of the EP4 receptor. Thus, in addition to the enhancement of macrophage adhesion, SR-A binding to gluc-collagen stimulates PG production, which in turn, differentially regulates the expression of inflammatory cytokines." @default.
• W2024586196 created "2016-06-24" @default.
• W2024586196 creator A5016540471 @default.
• W2024586196 creator A5026164472 @default.
• W2024586196 creator A5030705697 @default.
• W2024586196 creator A5037616534 @default.
• W2024586196 creator A5072993114 @default.
• W2024586196 creator A5088954090 @default.
• W2024586196 date "2015-02-25" @default.
• W2024586196 modified "2023-09-26" @default.
• W2024586196 title "Prostaglandins produced during class A scavenger receptor-mediated macrophage adhesion differentially regulate cytokine production" @default.
• W2024586196 cites W1569167561 @default.
• W2024586196 cites W1586297781 @default.
• W2024586196 cites W1586921439 @default.
• W2024586196 cites W1821668606 @default.
• W2024586196 cites W1921813710 @default.
• W2024586196 cites W1966312417 @default.
• W2024586196 cites W1968668179 @default.
• W2024586196 cites W1985829398 @default.
• W2024586196 cites W1994946013 @default.
• W2024586196 cites W2006176835 @default.
• W2024586196 cites W2007886054 @default.
• W2024586196 cites W2009898720 @default.
• W2024586196 cites W2010328277 @default.
• W2024586196 cites W2020448998 @default.
• W2024586196 cites W2023997718 @default.
• W2024586196 cites W2028906750 @default.
• W2024586196 cites W2037603180 @default.
• W2024586196 cites W2041016354 @default.
• W2024586196 cites W2045560271 @default.
• W2024586196 cites W2061448989 @default.
• W2024586196 cites W2075879675 @default.
• W2024586196 cites W2087766001 @default.
• W2024586196 cites W2107307747 @default.
• W2024586196 cites W2116691163 @default.
• W2024586196 cites W2126043069 @default.
• W2024586196 cites W2130348731 @default.
• W2024586196 cites W2138877935 @default.
• W2024586196 cites W2164047434 @default.
• W2024586196 doi "https://doi.org/10.1189/jlb.2a1014-471rr" @default.
• W2024586196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8454924" @default.
• W2024586196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25717147" @default.
• W2024586196 hasPublicationYear "2015" @default.
• W2024586196 type Work @default.
• W2024586196 sameAs 2024586196 @default.
• W2024586196 citedByCount "7" @default.
• W2024586196 countsByYear W20245861962016 @default.
• W2024586196 countsByYear W20245861962017 @default.
• W2024586196 countsByYear W20245861962019 @default.
• W2024586196 crossrefType "journal-article" @default.
• W2024586196 hasAuthorship W2024586196A5016540471 @default.
• W2024586196 hasAuthorship W2024586196A5026164472 @default.
• W2024586196 hasAuthorship W2024586196A5030705697 @default.
• W2024586196 hasAuthorship W2024586196A5037616534 @default.
• W2024586196 hasAuthorship W2024586196A5072993114 @default.
• W2024586196 hasAuthorship W2024586196A5088954090 @default.
• W2024586196 hasBestOaLocation W20245861961 @default.
• W2024586196 hasConcept C134018914 @default.
• W2024586196 hasConcept C1491633281 @default.
• W2024586196 hasConcept C170493617 @default.
• W2024586196 hasConcept C202751555 @default.
• W2024586196 hasConcept C203014093 @default.
• W2024586196 hasConcept C2776914184 @default.
• W2024586196 hasConcept C2778163477 @default.
• W2024586196 hasConcept C2778690821 @default.
• W2024586196 hasConcept C2779244956 @default.
• W2024586196 hasConcept C2780072125 @default.
• W2024586196 hasConcept C41443022 @default.
• W2024586196 hasConcept C55493867 @default.
• W2024586196 hasConcept C85789140 @default.
• W2024586196 hasConcept C86803240 @default.
• W2024586196 hasConcept C95444343 @default.
• W2024586196 hasConceptScore W2024586196C134018914 @default.
• W2024586196 hasConceptScore W2024586196C1491633281 @default.
• W2024586196 hasConceptScore W2024586196C170493617 @default.
• W2024586196 hasConceptScore W2024586196C202751555 @default.
• W2024586196 hasConceptScore W2024586196C203014093 @default.
• W2024586196 hasConceptScore W2024586196C2776914184 @default.
• W2024586196 hasConceptScore W2024586196C2778163477 @default.
• W2024586196 hasConceptScore W2024586196C2778690821 @default.
• W2024586196 hasConceptScore W2024586196C2779244956 @default.
• W2024586196 hasConceptScore W2024586196C2780072125 @default.
• W2024586196 hasConceptScore W2024586196C41443022 @default.
• W2024586196 hasConceptScore W2024586196C55493867 @default.
• W2024586196 hasConceptScore W2024586196C85789140 @default.
• W2024586196 hasConceptScore W2024586196C86803240 @default.
• W2024586196 hasConceptScore W2024586196C95444343 @default.
• W2024586196 hasFunder F4320332161 @default.
• W2024586196 hasFunder F4320337338 @default.
• W2024586196 hasIssue "5" @default.
• W2024586196 hasLocation W20245861961 @default.
• W2024586196 hasLocation W20245861962 @default.
• W2024586196 hasLocation W20245861963 @default.
• W2024586196 hasOpenAccess W2024586196 @default.
• W2024586196 hasPrimaryLocation W20245861961 @default.
• W2024586196 hasRelatedWork W1497439699 @default.
• W2024586196 hasRelatedWork W2001112073 @default.
• W2024586196 hasRelatedWork W2003794644 @default.

• next