Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024587613> ?p ?o ?g. }
- W2024587613 endingPage "1846" @default.
- W2024587613 startingPage "1842" @default.
- W2024587613 abstract "It is well-known that many patients with asthma undergo clinical improvement during a stay at high altitude. At high altitude, the atmospheric and climatic conditions (such as hypoxia, cold and dry air inhalation) could modify the bronchial responsiveness in asthmatics. Our study was designed to assess the difference in bronchial responsiveness to hypotonic aerosol between sea level and high altitudes in nonresident asthmatic subjects. The results were obtained during two mountaineering expeditions above 4,000 m i.e. at 4,559 m on Mt Rosa, Italy; and at 5,050 m near the Mt Everest base camp in Nepal. Eleven mild asthmatics performed standard bronchial challenges with ultrasonically nebulized distilled water (5 min inhalation, delivery 2 mL-min-1) at sea level and after staying at least 72 h at the above mentioned altitudes. The decrease in forced expiratory volume in one second (FEV1) from baseline was used as index of bronchial response. There was no significant difference in pre-challenge FEV1 between sea level and high altitude in either study. However, the bronchoconstriction response to ultrasonically nebulized distilled water was significantly reduced at high altitude in both studies. At sea level the mean FEV1 decrease was 22.2% (range 15-35%), whereas as the maximal altitude it was 6.7% (range 2-11%). Our results indicate that there is a reduction in bronchial responsiveness to hypoosmolar aerosol at high altitude. This suggests that atmospheric and climatic conditions, or physiological adaptations, via mediators such as atrial natriuretic peptide, are beneficial to patients with asthma at high altitude." @default.
- W2024587613 created "2016-06-24" @default.
- W2024587613 creator A5039074334 @default.
- W2024587613 creator A5046500067 @default.
- W2024587613 creator A5054484458 @default.
- W2024587613 creator A5054682390 @default.
- W2024587613 creator A5061715659 @default.
- W2024587613 creator A5072539306 @default.
- W2024587613 date "1995-11-01" @default.
- W2024587613 modified "2023-10-11" @default.
- W2024587613 title "High altitude exposure reduces bronchial responsiveness to hypo-osmolar aerosol in lowland asthmatics" @default.
- W2024587613 cites W139388767 @default.
- W2024587613 cites W1595693628 @default.
- W2024587613 cites W1703458271 @default.
- W2024587613 cites W1911706283 @default.
- W2024587613 cites W1975767536 @default.
- W2024587613 cites W1978601483 @default.
- W2024587613 cites W1984521943 @default.
- W2024587613 cites W1986123208 @default.
- W2024587613 cites W2008652305 @default.
- W2024587613 cites W2029881704 @default.
- W2024587613 cites W2032371888 @default.
- W2024587613 cites W2033529475 @default.
- W2024587613 cites W2037202323 @default.
- W2024587613 cites W2042587185 @default.
- W2024587613 cites W2055994540 @default.
- W2024587613 cites W2068392731 @default.
- W2024587613 cites W2068811543 @default.
- W2024587613 cites W2071527107 @default.
- W2024587613 cites W2084383899 @default.
- W2024587613 cites W2085518088 @default.
- W2024587613 cites W2101823334 @default.
- W2024587613 cites W2128239161 @default.
- W2024587613 cites W2130483093 @default.
- W2024587613 cites W2143203540 @default.
- W2024587613 cites W2180494637 @default.
- W2024587613 cites W2411925315 @default.
- W2024587613 cites W2413759952 @default.
- W2024587613 cites W59212126 @default.
- W2024587613 cites W1669531451 @default.
- W2024587613 doi "https://doi.org/10.1183/09031936.95.08111842" @default.
- W2024587613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8620949" @default.
- W2024587613 hasPublicationYear "1995" @default.
- W2024587613 type Work @default.
- W2024587613 sameAs 2024587613 @default.
- W2024587613 citedByCount "40" @default.
- W2024587613 countsByYear W20245876132012 @default.
- W2024587613 countsByYear W20245876132013 @default.
- W2024587613 countsByYear W20245876132014 @default.
- W2024587613 countsByYear W20245876132016 @default.
- W2024587613 countsByYear W20245876132018 @default.
- W2024587613 countsByYear W20245876132022 @default.
- W2024587613 crossrefType "journal-article" @default.
- W2024587613 hasAuthorship W2024587613A5039074334 @default.
- W2024587613 hasAuthorship W2024587613A5046500067 @default.
- W2024587613 hasAuthorship W2024587613A5054484458 @default.
- W2024587613 hasAuthorship W2024587613A5054682390 @default.
- W2024587613 hasAuthorship W2024587613A5061715659 @default.
- W2024587613 hasAuthorship W2024587613A5072539306 @default.
- W2024587613 hasBestOaLocation W20245876131 @default.
- W2024587613 hasConcept C105702510 @default.
- W2024587613 hasConcept C126322002 @default.
- W2024587613 hasConcept C2524010 @default.
- W2024587613 hasConcept C2776042228 @default.
- W2024587613 hasConcept C2776954882 @default.
- W2024587613 hasConcept C2780769369 @default.
- W2024587613 hasConcept C33923547 @default.
- W2024587613 hasConcept C42219234 @default.
- W2024587613 hasConcept C6350597 @default.
- W2024587613 hasConcept C71924100 @default.
- W2024587613 hasConcept C8240015 @default.
- W2024587613 hasConceptScore W2024587613C105702510 @default.
- W2024587613 hasConceptScore W2024587613C126322002 @default.
- W2024587613 hasConceptScore W2024587613C2524010 @default.
- W2024587613 hasConceptScore W2024587613C2776042228 @default.
- W2024587613 hasConceptScore W2024587613C2776954882 @default.
- W2024587613 hasConceptScore W2024587613C2780769369 @default.
- W2024587613 hasConceptScore W2024587613C33923547 @default.
- W2024587613 hasConceptScore W2024587613C42219234 @default.
- W2024587613 hasConceptScore W2024587613C6350597 @default.
- W2024587613 hasConceptScore W2024587613C71924100 @default.
- W2024587613 hasConceptScore W2024587613C8240015 @default.
- W2024587613 hasIssue "11" @default.
- W2024587613 hasLocation W20245876131 @default.
- W2024587613 hasLocation W20245876132 @default.
- W2024587613 hasOpenAccess W2024587613 @default.
- W2024587613 hasPrimaryLocation W20245876131 @default.
- W2024587613 hasRelatedWork W2064897698 @default.
- W2024587613 hasRelatedWork W2071320627 @default.
- W2024587613 hasRelatedWork W2089822011 @default.
- W2024587613 hasRelatedWork W2105048679 @default.
- W2024587613 hasRelatedWork W2114337266 @default.
- W2024587613 hasRelatedWork W2143490811 @default.
- W2024587613 hasRelatedWork W2355999728 @default.
- W2024587613 hasRelatedWork W2365078270 @default.
- W2024587613 hasRelatedWork W2945563562 @default.
- W2024587613 hasRelatedWork W4247701964 @default.
- W2024587613 hasVolume "8" @default.