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- W2024589987 abstract "γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II)-dependent oxygenase that catalyses the final step of l-carnitine biosynthesis in animals. BBOX catalyses the oxidation of 3-(2,2,2-trimethylhydrazinium)propionate (THP), a clinically used BBOX inhibitor, to form multiple products including 3-amino-4-(methyamino)butanoic acid (AMBA), which is proposed to be formed via a Stevens type rearrangement mechanism. We report the synthesis of AMBA and confirm that it is a product of the BBOX catalysed oxidation of THP. AMBA reacts with formaldehyde, which is produced enzymatically by BBOX, to give a cyclic adduct." @default.
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- W2024589987 date "2012-08-01" @default.
- W2024589987 modified "2023-09-27" @default.
- W2024589987 title "γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement" @default.
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- W2024589987 doi "https://doi.org/10.1016/j.bmcl.2012.06.024" @default.
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