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- W2024590953 abstract "Self-regulation is one of the most intriguing properties of early embryos. In 1924, Spemann and Mangold carried out the most famous experiment in experimental embryology, which led to the identification of the first self-organizing centre — the Spemann's organizer. In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncovered that cells in signalling centres that are located at the dorsal and ventral poles of the gastrula embryo communicate with each other through a network of secreted growth-factor antagonists, a protease that degrades them, a protease inhibitor and bone-morphogenic-protein signals." @default.
- W2024590953 created "2016-06-24" @default.
- W2024590953 creator A5001643742 @default.
- W2024590953 date "2006-02-01" @default.
- W2024590953 modified "2023-09-29" @default.
- W2024590953 title "Spemann's organizer and self-regulation in amphibian embryos" @default.
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- W2024590953 doi "https://doi.org/10.1038/nrm1855" @default.
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