FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024590979> ?p ?o ?g. }

• W2024590979 endingPage "e4317" @default.
• W2024590979 startingPage "e4317" @default.
• W2024590979 abstract "Introduction The causes of coma and death in cerebral malaria remain unknown. Malarial retinopathy has been identified as an important clinical sign in the diagnosis and prognosis of cerebral malaria. As part of a larger autopsy study to determine causes of death in children with coma presenting to hospital in Blantyre, Malawi, who were fully evaluated clinically prior to death, we examined the histopathology of eyes of patients who died and underwent autopsy. Methodology/Principal Findings Children with coma were admitted to the pediatric research ward, classified according to clinical definitions as having cerebral malaria or another cause of coma, evaluated and treated. The eyes were examined by direct and indirect ophthalmoscopy. If a child died and permission was given, a standardized autopsy was carried out. The patient was then assigned an actual cause of death according to the autopsy findings. The eyes were examined pathologically for hemorrhages, cystoid macular edema, parasite sequestration and thrombi. They were stained immunohistochemically for fibrin and CD61 to identify the components of thrombi, β-amyloid precursor protein to detect axonal damage, for fibrinogen to identify vascular leakage and for glial fibrillary acidic protein to detect gliosis. Sixty-four eyes from 64 patients were examined: 35 with cerebral malaria and 29 with comas of other causes. Cerebral malaria was distinguished by sequestration of parasitized erythrocytes, the presence and severity of retinal hemorrhages, the presence of cystoid macular edema, the occurrence and number of fibrin-platelet thrombi, the presence and amount of axonal damage and vascular leakage. Conclusions/Significance We found significant differences in retinal histopathology between patients who died of cerebral malaria and those with other diagnoses. These histopathological findings offer insights into the etiology of malarial retinopathy and provide a pathological basis for recently described retinal capillary non-perfusion in children with malarial retinopathy. Because of the similarities between the retina and the brain it also suggests mechanisms that may contribute to coma and death in cerebral malaria." @default.
• W2024590979 created "2016-06-24" @default.
• W2024590979 creator A5009618897 @default.
• W2024590979 creator A5015436088 @default.
• W2024590979 creator A5029075663 @default.
• W2024590979 creator A5033337244 @default.
• W2024590979 creator A5063491233 @default.
• W2024590979 date "2009-01-29" @default.
• W2024590979 modified "2023-09-25" @default.
• W2024590979 title "Retinal Pathology of Pediatric Cerebral Malaria in Malawi" @default.
• W2024590979 cites W127872553 @default.
• W2024590979 cites W1955203614 @default.
• W2024590979 cites W1971788544 @default.
• W2024590979 cites W1972468142 @default.
• W2024590979 cites W1989873077 @default.
• W2024590979 cites W1996955283 @default.
• W2024590979 cites W2003465978 @default.
• W2024590979 cites W2009541928 @default.
• W2024590979 cites W2021063311 @default.
• W2024590979 cites W2023353865 @default.
• W2024590979 cites W2035447238 @default.
• W2024590979 cites W2051152590 @default.
• W2024590979 cites W2068546343 @default.
• W2024590979 cites W2069221377 @default.
• W2024590979 cites W2079957682 @default.
• W2024590979 cites W2085477803 @default.
• W2024590979 cites W2086651792 @default.
• W2024590979 cites W2090613637 @default.
• W2024590979 cites W2092313569 @default.
• W2024590979 cites W2093985626 @default.
• W2024590979 cites W2113538084 @default.
• W2024590979 cites W2119641374 @default.
• W2024590979 cites W2134164686 @default.
• W2024590979 cites W2137698029 @default.
• W2024590979 cites W2145823987 @default.
• W2024590979 cites W2159451467 @default.
• W2024590979 cites W2186101998 @default.
• W2024590979 cites W2400419733 @default.
• W2024590979 cites W4230290064 @default.
• W2024590979 doi "https://doi.org/10.1371/journal.pone.0004317" @default.
• W2024590979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2627904" @default.
• W2024590979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19177166" @default.
• W2024590979 hasPublicationYear "2009" @default.
• W2024590979 type Work @default.
• W2024590979 sameAs 2024590979 @default.
• W2024590979 citedByCount "95" @default.
• W2024590979 countsByYear W20245909792012 @default.
• W2024590979 countsByYear W20245909792013 @default.
• W2024590979 countsByYear W20245909792014 @default.
• W2024590979 countsByYear W20245909792015 @default.
• W2024590979 countsByYear W20245909792016 @default.
• W2024590979 countsByYear W20245909792017 @default.
• W2024590979 countsByYear W20245909792018 @default.
• W2024590979 countsByYear W20245909792019 @default.
• W2024590979 countsByYear W20245909792020 @default.
• W2024590979 countsByYear W20245909792021 @default.
• W2024590979 countsByYear W20245909792022 @default.
• W2024590979 countsByYear W20245909792023 @default.
• W2024590979 crossrefType "journal-article" @default.
• W2024590979 hasAuthorship W2024590979A5009618897 @default.
• W2024590979 hasAuthorship W2024590979A5015436088 @default.
• W2024590979 hasAuthorship W2024590979A5029075663 @default.
• W2024590979 hasAuthorship W2024590979A5033337244 @default.
• W2024590979 hasAuthorship W2024590979A5063491233 @default.
• W2024590979 hasBestOaLocation W20245909791 @default.
• W2024590979 hasConcept C100136789 @default.
• W2024590979 hasConcept C118494813 @default.
• W2024590979 hasConcept C119767625 @default.
• W2024590979 hasConcept C120665830 @default.
• W2024590979 hasConcept C121332964 @default.
• W2024590979 hasConcept C126322002 @default.
• W2024590979 hasConcept C141071460 @default.
• W2024590979 hasConcept C142724271 @default.
• W2024590979 hasConcept C203014093 @default.
• W2024590979 hasConcept C204232928 @default.
• W2024590979 hasConcept C2777682930 @default.
• W2024590979 hasConcept C2778048844 @default.
• W2024590979 hasConcept C2778371730 @default.
• W2024590979 hasConcept C2779134260 @default.
• W2024590979 hasConcept C2779493303 @default.
• W2024590979 hasConcept C2779504383 @default.
• W2024590979 hasConcept C2780495277 @default.
• W2024590979 hasConcept C2780929884 @default.
• W2024590979 hasConcept C2781458274 @default.
• W2024590979 hasConcept C2908793570 @default.
• W2024590979 hasConcept C2910405079 @default.
• W2024590979 hasConcept C29374701 @default.
• W2024590979 hasConcept C54173615 @default.
• W2024590979 hasConcept C71924100 @default.
• W2024590979 hasConceptScore W2024590979C100136789 @default.
• W2024590979 hasConceptScore W2024590979C118494813 @default.
• W2024590979 hasConceptScore W2024590979C119767625 @default.
• W2024590979 hasConceptScore W2024590979C120665830 @default.
• W2024590979 hasConceptScore W2024590979C121332964 @default.
• W2024590979 hasConceptScore W2024590979C126322002 @default.
• W2024590979 hasConceptScore W2024590979C141071460 @default.
• W2024590979 hasConceptScore W2024590979C142724271 @default.
• W2024590979 hasConceptScore W2024590979C203014093 @default.

• next