Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024591824> ?p ?o ?g. }
- W2024591824 endingPage "e1003049" @default.
- W2024591824 startingPage "e1003049" @default.
- W2024591824 abstract "The mechanisms of cell cycle exit by neurons remain poorly understood. Through genetic and developmental analysis of Drosophila eye development, we found that the cyclin-dependent kinase-inhibitor Roughex maintains G1 cell cycle exit during differentiation of the R8 class of photoreceptor neurons. The roughex mutant neurons re-enter the mitotic cell cycle and progress without executing cytokinesis, unlike non-neuronal cells in the roughex mutant that perform complete cell divisions. After mitosis, the binucleated R8 neurons usually transport one daughter nucleus away from the cell body into the developing axon towards the brain in a kinesin-dependent manner resembling anterograde axonal trafficking. Similar cell cycle and photoreceptor neuron defects occurred in mutants for components of the Anaphase Promoting Complex/Cyclosome. These findings indicate a neuron-specific defect in cytokinesis and demonstrate a critical role for mitotic cyclin downregulation both to maintain cell cycle exit during neuronal differentiation and to prevent axonal defects following failed cytokinesis." @default.
- W2024591824 created "2016-06-24" @default.
- W2024591824 creator A5002565932 @default.
- W2024591824 creator A5025350204 @default.
- W2024591824 creator A5028529010 @default.
- W2024591824 creator A5041673594 @default.
- W2024591824 date "2012-11-29" @default.
- W2024591824 modified "2023-10-05" @default.
- W2024591824 title "Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Drosophila Photoreceptor Neurons" @default.
- W2024591824 cites W1552046925 @default.
- W2024591824 cites W1566225830 @default.
- W2024591824 cites W160687248 @default.
- W2024591824 cites W1607040929 @default.
- W2024591824 cites W1751857692 @default.
- W2024591824 cites W1804270252 @default.
- W2024591824 cites W183102203 @default.
- W2024591824 cites W1856652139 @default.
- W2024591824 cites W1965505970 @default.
- W2024591824 cites W1967897970 @default.
- W2024591824 cites W1977365775 @default.
- W2024591824 cites W1977920071 @default.
- W2024591824 cites W1986917337 @default.
- W2024591824 cites W1987444426 @default.
- W2024591824 cites W1990743609 @default.
- W2024591824 cites W1991290236 @default.
- W2024591824 cites W1991631964 @default.
- W2024591824 cites W1996061686 @default.
- W2024591824 cites W1997589405 @default.
- W2024591824 cites W1998015574 @default.
- W2024591824 cites W2001762363 @default.
- W2024591824 cites W2002141723 @default.
- W2024591824 cites W2006229889 @default.
- W2024591824 cites W2013603496 @default.
- W2024591824 cites W2013759589 @default.
- W2024591824 cites W2014682544 @default.
- W2024591824 cites W2014957927 @default.
- W2024591824 cites W2016402179 @default.
- W2024591824 cites W2026619895 @default.
- W2024591824 cites W2029171147 @default.
- W2024591824 cites W2030191254 @default.
- W2024591824 cites W2033306271 @default.
- W2024591824 cites W2033599203 @default.
- W2024591824 cites W2035508405 @default.
- W2024591824 cites W2037624113 @default.
- W2024591824 cites W2039201695 @default.
- W2024591824 cites W2041372335 @default.
- W2024591824 cites W2044168912 @default.
- W2024591824 cites W2046666752 @default.
- W2024591824 cites W2051202415 @default.
- W2024591824 cites W2061145246 @default.
- W2024591824 cites W2062452071 @default.
- W2024591824 cites W2070651150 @default.
- W2024591824 cites W2074796477 @default.
- W2024591824 cites W2076392163 @default.
- W2024591824 cites W2076840943 @default.
- W2024591824 cites W2080154266 @default.
- W2024591824 cites W2080695871 @default.
- W2024591824 cites W2081124673 @default.
- W2024591824 cites W2084307062 @default.
- W2024591824 cites W2085204257 @default.
- W2024591824 cites W2085523100 @default.
- W2024591824 cites W2089218510 @default.
- W2024591824 cites W2090698995 @default.
- W2024591824 cites W2090827556 @default.
- W2024591824 cites W2092598865 @default.
- W2024591824 cites W2106301228 @default.
- W2024591824 cites W2117634579 @default.
- W2024591824 cites W2124981784 @default.
- W2024591824 cites W2125635130 @default.
- W2024591824 cites W2128705810 @default.
- W2024591824 cites W2136580888 @default.
- W2024591824 cites W2141877830 @default.
- W2024591824 cites W2144942522 @default.
- W2024591824 cites W2150972545 @default.
- W2024591824 cites W2151140509 @default.
- W2024591824 cites W2152018084 @default.
- W2024591824 cites W2155970893 @default.
- W2024591824 cites W2157326524 @default.
- W2024591824 cites W2157443774 @default.
- W2024591824 cites W2206700112 @default.
- W2024591824 cites W311467598 @default.
- W2024591824 cites W72407265 @default.
- W2024591824 doi "https://doi.org/10.1371/journal.pgen.1003049" @default.
- W2024591824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3510051" @default.
- W2024591824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23209426" @default.
- W2024591824 hasPublicationYear "2012" @default.
- W2024591824 type Work @default.
- W2024591824 sameAs 2024591824 @default.
- W2024591824 citedByCount "19" @default.
- W2024591824 countsByYear W20245918242013 @default.
- W2024591824 countsByYear W20245918242014 @default.
- W2024591824 countsByYear W20245918242015 @default.
- W2024591824 countsByYear W20245918242017 @default.
- W2024591824 countsByYear W20245918242020 @default.
- W2024591824 countsByYear W20245918242021 @default.
- W2024591824 countsByYear W20245918242022 @default.
- W2024591824 crossrefType "journal-article" @default.
- W2024591824 hasAuthorship W2024591824A5002565932 @default.