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- W2024593172 abstract "GABA level and the activity of L-glutamate-1-decarboxylase (GAD) (EC 4.1.1.15) were studied in brains of mice treated with beta-vinyllactic acid, a new, selective and pyridoxal phosphate-independent GAD inhibitor. Valproate and diazepam protected mice against convulsions caused by beta-vinyllactic acid although both anti-epileptic drugs antagonized neither the decrease in GABA concentrations nor the inhibition of GAD observed after treatment with beta-vinyllactic acid alone. Assuming that the anticonvulsant effect measured with both antiepileptics is GABA mediated, these results support the hypothesis of a postsynaptic enhancement of GABAergic transmission by diazepam and valproate." @default.
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- W2024593172 date "1984-06-01" @default.
- W2024593172 modified "2023-09-26" @default.
- W2024593172 title "Protective effects of diazepam and valproate on β-vinyllactic acid-induced seizures" @default.
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- W2024593172 doi "https://doi.org/10.1016/0304-3940(84)90536-6" @default.
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