FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024595059> ?p ?o ?g. }

• W2024595059 endingPage "562" @default.
• W2024595059 startingPage "548" @default.
• W2024595059 abstract "Mutations in the mitochondrial fusion gene Mfn2 cause the human neurodegenerative disease Charcot-Marie-Tooth type 2A. However, the cellular basis underlying this relationship is poorly understood. By removing Mfn2 from the cerebellum, we established a model for neurodegeneration caused by loss of mitochondrial fusion. During development and after maturity, Purkinje cells require Mfn2 but not Mfn1 for dendritic outgrowth, spine formation, and cell survival. In vivo, cell culture, and electron microscopy studies indicate that mutant Purkinje cells have aberrant mitochondrial distribution, ultrastructure, and electron transport chain activity. In fibroblasts lacking mitochondrial fusion, the majority of mitochondria lack mitochondrial DNA nucleoids. This deficiency provides a molecular mechanism for the dependence of respiratory activity on mitochondrial fusion. Our results show that exchange of mitochondrial contents is important for mitochondrial function as well as organelle distribution in neurons and have important implications for understanding the mechanisms of neurodegeneration due to perturbations in mitochondrial fusion." @default.
• W2024595059 created "2016-06-24" @default.
• W2024595059 creator A5005551232 @default.
• W2024595059 creator A5044081797 @default.
• W2024595059 creator A5052542033 @default.
• W2024595059 date "2007-08-01" @default.
• W2024595059 modified "2023-10-13" @default.
• W2024595059 title "Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum" @default.
• W2024595059 cites W1589803235 @default.
• W2024595059 cites W1967445833 @default.
• W2024595059 cites W1970243208 @default.
• W2024595059 cites W1974750801 @default.
• W2024595059 cites W1986996580 @default.
• W2024595059 cites W1989540421 @default.
• W2024595059 cites W1993490757 @default.
• W2024595059 cites W1995499476 @default.
• W2024595059 cites W1998964174 @default.
• W2024595059 cites W2003426511 @default.
• W2024595059 cites W2014229034 @default.
• W2024595059 cites W2023542615 @default.
• W2024595059 cites W2027279589 @default.
• W2024595059 cites W2032036929 @default.
• W2024595059 cites W2037174767 @default.
• W2024595059 cites W2039409049 @default.
• W2024595059 cites W2040118243 @default.
• W2024595059 cites W2044494908 @default.
• W2024595059 cites W2045005785 @default.
• W2024595059 cites W2045085957 @default.
• W2024595059 cites W2057289695 @default.
• W2024595059 cites W2058172887 @default.
• W2024595059 cites W2060811345 @default.
• W2024595059 cites W2066575706 @default.
• W2024595059 cites W2067270063 @default.
• W2024595059 cites W2071229320 @default.
• W2024595059 cites W2073095545 @default.
• W2024595059 cites W2084606607 @default.
• W2024595059 cites W2085441242 @default.
• W2024595059 cites W2091331379 @default.
• W2024595059 cites W2094113524 @default.
• W2024595059 cites W2098287644 @default.
• W2024595059 cites W2104380910 @default.
• W2024595059 cites W2107736130 @default.
• W2024595059 cites W2124140045 @default.
• W2024595059 cites W2127271204 @default.
• W2024595059 cites W2130758099 @default.
• W2024595059 cites W2135621635 @default.
• W2024595059 cites W2148471604 @default.
• W2024595059 cites W2152913938 @default.
• W2024595059 cites W2158218054 @default.
• W2024595059 cites W2161437961 @default.
• W2024595059 cites W2171776741 @default.
• W2024595059 doi "https://doi.org/10.1016/j.cell.2007.06.026" @default.
• W2024595059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17693261" @default.
• W2024595059 hasPublicationYear "2007" @default.
• W2024595059 type Work @default.
• W2024595059 sameAs 2024595059 @default.
• W2024595059 citedByCount "789" @default.
• W2024595059 countsByYear W20245950592012 @default.
• W2024595059 countsByYear W20245950592013 @default.
• W2024595059 countsByYear W20245950592014 @default.
• W2024595059 countsByYear W20245950592015 @default.
• W2024595059 countsByYear W20245950592016 @default.
• W2024595059 countsByYear W20245950592017 @default.
• W2024595059 countsByYear W20245950592018 @default.
• W2024595059 countsByYear W20245950592019 @default.
• W2024595059 countsByYear W20245950592020 @default.
• W2024595059 countsByYear W20245950592021 @default.
• W2024595059 countsByYear W20245950592022 @default.
• W2024595059 countsByYear W20245950592023 @default.
• W2024595059 crossrefType "journal-article" @default.
• W2024595059 hasAuthorship W2024595059A5005551232 @default.
• W2024595059 hasAuthorship W2024595059A5044081797 @default.
• W2024595059 hasAuthorship W2024595059A5052542033 @default.
• W2024595059 hasBestOaLocation W20245950591 @default.
• W2024595059 hasConcept C104317684 @default.
• W2024595059 hasConcept C111491248 @default.
• W2024595059 hasConcept C142724271 @default.
• W2024595059 hasConcept C1491633281 @default.
• W2024595059 hasConcept C163950672 @default.
• W2024595059 hasConcept C17619807 @default.
• W2024595059 hasConcept C24586158 @default.
• W2024595059 hasConcept C2776925932 @default.
• W2024595059 hasConcept C2777092462 @default.
• W2024595059 hasConcept C2777591492 @default.
• W2024595059 hasConcept C2779134260 @default.
• W2024595059 hasConcept C28859421 @default.
• W2024595059 hasConcept C54355233 @default.
• W2024595059 hasConcept C71924100 @default.
• W2024595059 hasConcept C86803240 @default.
• W2024595059 hasConcept C92488253 @default.
• W2024595059 hasConcept C95444343 @default.
• W2024595059 hasConceptScore W2024595059C104317684 @default.
• W2024595059 hasConceptScore W2024595059C111491248 @default.
• W2024595059 hasConceptScore W2024595059C142724271 @default.
• W2024595059 hasConceptScore W2024595059C1491633281 @default.
• W2024595059 hasConceptScore W2024595059C163950672 @default.
• W2024595059 hasConceptScore W2024595059C17619807 @default.
• W2024595059 hasConceptScore W2024595059C24586158 @default.

• next