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- W2024596209 abstract "An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile ‘click’ chemistry, this versatile intermediate can be further functionalised to explore antimicrobial structure–activity relationships or conjugated to fluorophores to generate fluorescent probes. Such probes can report bacteria and their location in a sample in real time. Modelling of the structures bound to the cognate 50S ribosome target demonstrates binding to the same site as linezolid is possible. The fluorescent probes were successfully used to image Gram-positive bacteria using confocal microscopy." @default.
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- W2024596209 date "2014-08-01" @default.
- W2024596209 modified "2023-10-17" @default.
- W2024596209 title "An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants" @default.
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- W2024596209 doi "https://doi.org/10.1016/j.bmc.2014.05.054" @default.
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