FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024596916> ?p ?o ?g. }

• W2024596916 abstract "The possible presence of a high affinity uptake mechanism for dopamine and the metabolism of this amine was investigated in the rabbit carotid body. The type I cells of this sensory organ contain high levels of dopamine and share with sympathetic nerve endings (which possess a high affinity uptake mechanism for catecholamines) the properties of being presynaptic catecholaminergic elements, but also have in common with chromaffin cells from intact adrenal medulla (which lack a high affinity catecholamine uptake) a similar embryological origin and ultrastructural appearance. Our experiments revealed only a low affinity uptake process (Km = 6.76 X 10(-4) M [3H]dopamine; Vmax = 1.84 X 10(-9) mol [3H]dopamine/mg protein/min) in the rabbit carotid body. In agreement with our kinetic findings, the uptake of [3H]dopamine was found to be independent of the Na+ concentration in the incubation media. The efflux from the tissue of incorporated [3H]dopamine was very fast (88% wash-out with a half-time of 4 min). DOPAC was the principal catabolite of dopamine in the carotid body, and the organ exhibited a very low capacity for norepinephrine synthesis. Neither chronic carotid sinus nerve section nor chronic sympathectomy modified the uptake of [3H]dopamine, suggesting that the lack of expression of a high affinity uptake was not a consequence of trophic suppression by the neural innervation of the organ. We conclude that overflow, or wash-out, of released dopamine may be quantitatively the most important mechanism for the inactivation of this putative neurotransmitter in the rabbit carotid body." @default.
• W2024596916 created "2016-06-24" @default.
• W2024596916 creator A5067247871 @default.
• W2024596916 creator A5071750021 @default.
• W2024596916 creator A5081391220 @default.
• W2024596916 creator A5088756262 @default.
• W2024596916 date "1987-03-01" @default.
• W2024596916 modified "2023-09-27" @default.
• W2024596916 title "Mechanisms for termination of the action of dopamine in carotid body chemoreceptors" @default.
• W2024596916 cites W1607584215 @default.
• W2024596916 cites W1632450738 @default.
• W2024596916 cites W1964528955 @default.
• W2024596916 cites W1965891828 @default.
• W2024596916 cites W1969321582 @default.
• W2024596916 cites W1980114985 @default.
• W2024596916 cites W1980657617 @default.
• W2024596916 cites W1982527406 @default.
• W2024596916 cites W1984055521 @default.
• W2024596916 cites W1998385128 @default.
• W2024596916 cites W2007027516 @default.
• W2024596916 cites W2009091316 @default.
• W2024596916 cites W2023276831 @default.
• W2024596916 cites W2032202178 @default.
• W2024596916 cites W2035775815 @default.
• W2024596916 cites W2036305202 @default.
• W2024596916 cites W2039900655 @default.
• W2024596916 cites W2041186027 @default.
• W2024596916 cites W2046305442 @default.
• W2024596916 cites W2047464518 @default.
• W2024596916 cites W2048705154 @default.
• W2024596916 cites W2049028919 @default.
• W2024596916 cites W2051031422 @default.
• W2024596916 cites W2052372767 @default.
• W2024596916 cites W2057808940 @default.
• W2024596916 cites W2070969718 @default.
• W2024596916 cites W2072358669 @default.
• W2024596916 cites W2072741191 @default.
• W2024596916 cites W2080165708 @default.
• W2024596916 cites W2082104269 @default.
• W2024596916 cites W2114168383 @default.
• W2024596916 cites W2120311544 @default.
• W2024596916 cites W2146807040 @default.
• W2024596916 cites W2164577723 @default.
• W2024596916 cites W2174930616 @default.
• W2024596916 cites W2316469876 @default.
• W2024596916 cites W2409665486 @default.
• W2024596916 cites W2461216031 @default.
• W2024596916 doi "https://doi.org/10.1016/0165-1838(87)90123-8" @default.
• W2024596916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3571830" @default.
• W2024596916 hasPublicationYear "1987" @default.
• W2024596916 type Work @default.
• W2024596916 sameAs 2024596916 @default.
• W2024596916 citedByCount "22" @default.
• W2024596916 countsByYear W20245969162015 @default.
• W2024596916 countsByYear W20245969162019 @default.
• W2024596916 crossrefType "journal-article" @default.
• W2024596916 hasAuthorship W2024596916A5067247871 @default.
• W2024596916 hasAuthorship W2024596916A5071750021 @default.
• W2024596916 hasAuthorship W2024596916A5081391220 @default.
• W2024596916 hasAuthorship W2024596916A5088756262 @default.
• W2024596916 hasConcept C126322002 @default.
• W2024596916 hasConcept C134018914 @default.
• W2024596916 hasConcept C137183658 @default.
• W2024596916 hasConcept C185592680 @default.
• W2024596916 hasConcept C236027 @default.
• W2024596916 hasConcept C24998067 @default.
• W2024596916 hasConcept C2775894120 @default.
• W2024596916 hasConcept C2776219046 @default.
• W2024596916 hasConcept C2776824294 @default.
• W2024596916 hasConcept C2777597313 @default.
• W2024596916 hasConcept C2778113364 @default.
• W2024596916 hasConcept C513476851 @default.
• W2024596916 hasConcept C529278444 @default.
• W2024596916 hasConcept C71924100 @default.
• W2024596916 hasConcept C86803240 @default.
• W2024596916 hasConceptScore W2024596916C126322002 @default.
• W2024596916 hasConceptScore W2024596916C134018914 @default.
• W2024596916 hasConceptScore W2024596916C137183658 @default.
• W2024596916 hasConceptScore W2024596916C185592680 @default.
• W2024596916 hasConceptScore W2024596916C236027 @default.
• W2024596916 hasConceptScore W2024596916C24998067 @default.
• W2024596916 hasConceptScore W2024596916C2775894120 @default.
• W2024596916 hasConceptScore W2024596916C2776219046 @default.
• W2024596916 hasConceptScore W2024596916C2776824294 @default.
• W2024596916 hasConceptScore W2024596916C2777597313 @default.
• W2024596916 hasConceptScore W2024596916C2778113364 @default.
• W2024596916 hasConceptScore W2024596916C513476851 @default.
• W2024596916 hasConceptScore W2024596916C529278444 @default.
• W2024596916 hasConceptScore W2024596916C71924100 @default.
• W2024596916 hasConceptScore W2024596916C86803240 @default.
• W2024596916 hasLocation W20245969161 @default.
• W2024596916 hasLocation W20245969162 @default.
• W2024596916 hasOpenAccess W2024596916 @default.
• W2024596916 hasPrimaryLocation W20245969161 @default.
• W2024596916 hasRelatedWork W1966309350 @default.
• W2024596916 hasRelatedWork W1968957541 @default.
• W2024596916 hasRelatedWork W1994169549 @default.
• W2024596916 hasRelatedWork W2009941709 @default.
• W2024596916 hasRelatedWork W2024596916 @default.
• W2024596916 hasRelatedWork W2048145699 @default.

• next