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• W2024598312 abstract "Abstract Background About 30-50% of Hodgkin lymphomas (HLs) harbor the Epstein-Barr virus (EBV), but the impact of EBV infection on clinical outcomes has been unclear. EBV-encoded small RNAs ( EBER s) are presented in all EBV-infected cells, but their functions are still less understood. Results EBER1 was transfected into two HL cell lines, KMH2 and L428, and microarrays were used to screen for EBER1 -induced changes. We found that EBER1 suppressed p21 cip1/waf1 transcription in HL cell lines. In addition, positive regulators of p21 cip1/waf1 transcription, such as p53, EGR1, and STAT1, were decreased. Suppression of p21 cip1/waf1 in the EBER1 + HL cell lines was associated with increased resistance to histone deacetylase inhibitors or proteasome inhibitors, drugs known to cause apoptosis by increasing p21 cip1/waf1 levels. On biopsy specimens, EBV + HLs had weaker expression of both p21 cip1/waf1 and active caspase 3. Clinically, suppression of p21 cip1/waf1 in EBV + HLs was associated with a worse 2-year disease-free survival rate (45% for EBV + HLs vs . 77% for EBV - HLs, p = 0.002). Conclusion Although the underlying mechanisms are still relatively unclear, EBER1 inhibits p21 cip1/waf1 transcription and prevents apoptosis through down-regulation of p53, EGR1, and STAT1. The anti-apoptotic activity of EBER1 may be important in the rescue of Reed-Sternberg cells from drug-induced apoptosis and in the clinical behaviors of EBV + HLs." @default.
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• W2024598312 date "2010-02-09" @default.
• W2024598312 modified "2023-10-16" @default.
• W2024598312 title "EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis" @default.
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• W2024598312 doi "https://doi.org/10.1186/1476-4598-9-32" @default.
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