FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024602110> ?p ?o ?g. }

• W2024602110 endingPage "363" @default.
• W2024602110 startingPage "357" @default.
• W2024602110 abstract "<i>Background:</i> Loss of heterozygosity (LOH) at 13q22 is a common event in nasopharyngeal carcinoma (NPC). <i>EDNRB</i> gene located at 13q22 has been demonstrated to be hypermethylated in some kinds of tumors. In the current study, we focused on the epigenetic and genetic alterations of <i>EDNRB</i> in NPC. <i>Methods:</i> The mRNA expression of <i>EDNRB</i> was detected by semiquantitative RT-PCR and real-time quantitative PCR in 49 NPC and 12 chronic nasopharyngitis biopsies. The methylation and LOH status of <i>EDNRB</i> were examined by methylation-specific polymerase chain reaction, microsatellite PCR and sequencing. We also examined the mRNA expression of <i>EDNRB</i> in four NPC cell lines after 5-aza-2′-deoxycytidine treatment. <i>Results:</i><i>EDNRB</i> was downregulated in primary NPC tissues and NPC cell lines, and a relatively higher methylation level of <i>EDNRB</i> was found in NPC biopsies (84%) compared to that in chronic nasopharyngitis biopsies (42%). Treatment of NPC cell lines with 5-aza-2′-deoxycytidine activated <i>EDNRB</i> expression. LOH of <i>EDNRB </i>gene was also found at two microsatellite sites with ratios of 6.25 and 16.67% in NPC. <i>Conclusion: </i>Our results suggested that <i>EDNRB</i> expression may be affected by aberrant promoter methylation and gene deletion and may play a role in the development of NPC." @default.
• W2024602110 created "2016-06-24" @default.
• W2024602110 creator A5008479914 @default.
• W2024602110 creator A5021833545 @default.
• W2024602110 creator A5030212756 @default.
• W2024602110 creator A5042643943 @default.
• W2024602110 creator A5042700675 @default.
• W2024602110 creator A5052950208 @default.
• W2024602110 creator A5062886930 @default.
• W2024602110 creator A5068194864 @default.
• W2024602110 creator A5071592619 @default.
• W2024602110 creator A5073216396 @default.
• W2024602110 date "2007-01-01" @default.
• W2024602110 modified "2023-09-27" @default.
• W2024602110 title "Epigenetic and Genetic Alterations of the <i>EDNRB</i> Gene in Nasopharyngeal Carcinoma" @default.
• W2024602110 cites W1548757985 @default.
• W2024602110 cites W1576536426 @default.
• W2024602110 cites W1966382767 @default.
• W2024602110 cites W1968263601 @default.
• W2024602110 cites W1972179955 @default.
• W2024602110 cites W1991189875 @default.
• W2024602110 cites W2005682191 @default.
• W2024602110 cites W2009327119 @default.
• W2024602110 cites W2018682541 @default.
• W2024602110 cites W2027707030 @default.
• W2024602110 cites W2030447420 @default.
• W2024602110 cites W2036490362 @default.
• W2024602110 cites W2043308960 @default.
• W2024602110 cites W2052707459 @default.
• W2024602110 cites W2055294254 @default.
• W2024602110 cites W2061243293 @default.
• W2024602110 cites W2062423918 @default.
• W2024602110 cites W2068123167 @default.
• W2024602110 cites W2069049696 @default.
• W2024602110 cites W2073428986 @default.
• W2024602110 cites W2079798771 @default.
• W2024602110 cites W2090729344 @default.
• W2024602110 cites W2111291753 @default.
• W2024602110 cites W2123238153 @default.
• W2024602110 cites W2130788521 @default.
• W2024602110 cites W2130809733 @default.
• W2024602110 cites W2133431301 @default.
• W2024602110 cites W2148263611 @default.
• W2024602110 cites W2171114945 @default.
• W2024602110 cites W2171788646 @default.
• W2024602110 cites W2240281720 @default.
• W2024602110 cites W2412675308 @default.
• W2024602110 doi "https://doi.org/10.1159/000113146" @default.
• W2024602110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18187958" @default.
• W2024602110 hasPublicationYear "2007" @default.
• W2024602110 type Work @default.
• W2024602110 sameAs 2024602110 @default.
• W2024602110 citedByCount "20" @default.
• W2024602110 countsByYear W20246021102012 @default.
• W2024602110 countsByYear W20246021102013 @default.
• W2024602110 countsByYear W20246021102014 @default.
• W2024602110 countsByYear W20246021102015 @default.
• W2024602110 countsByYear W20246021102019 @default.
• W2024602110 countsByYear W20246021102022 @default.
• W2024602110 crossrefType "journal-article" @default.
• W2024602110 hasAuthorship W2024602110A5008479914 @default.
• W2024602110 hasAuthorship W2024602110A5021833545 @default.
• W2024602110 hasAuthorship W2024602110A5030212756 @default.
• W2024602110 hasAuthorship W2024602110A5042643943 @default.
• W2024602110 hasAuthorship W2024602110A5042700675 @default.
• W2024602110 hasAuthorship W2024602110A5052950208 @default.
• W2024602110 hasAuthorship W2024602110A5062886930 @default.
• W2024602110 hasAuthorship W2024602110A5068194864 @default.
• W2024602110 hasAuthorship W2024602110A5071592619 @default.
• W2024602110 hasAuthorship W2024602110A5073216396 @default.
• W2024602110 hasConcept C104317684 @default.
• W2024602110 hasConcept C126322002 @default.
• W2024602110 hasConcept C143589142 @default.
• W2024602110 hasConcept C150194340 @default.
• W2024602110 hasConcept C153911025 @default.
• W2024602110 hasConcept C180754005 @default.
• W2024602110 hasConcept C190727270 @default.
• W2024602110 hasConcept C2778997737 @default.
• W2024602110 hasConcept C33288867 @default.
• W2024602110 hasConcept C41091548 @default.
• W2024602110 hasConcept C502942594 @default.
• W2024602110 hasConcept C509974204 @default.
• W2024602110 hasConcept C54355233 @default.
• W2024602110 hasConcept C71924100 @default.
• W2024602110 hasConcept C86803240 @default.
• W2024602110 hasConceptScore W2024602110C104317684 @default.
• W2024602110 hasConceptScore W2024602110C126322002 @default.
• W2024602110 hasConceptScore W2024602110C143589142 @default.
• W2024602110 hasConceptScore W2024602110C150194340 @default.
• W2024602110 hasConceptScore W2024602110C153911025 @default.
• W2024602110 hasConceptScore W2024602110C180754005 @default.
• W2024602110 hasConceptScore W2024602110C190727270 @default.
• W2024602110 hasConceptScore W2024602110C2778997737 @default.
• W2024602110 hasConceptScore W2024602110C33288867 @default.
• W2024602110 hasConceptScore W2024602110C41091548 @default.
• W2024602110 hasConceptScore W2024602110C502942594 @default.
• W2024602110 hasConceptScore W2024602110C509974204 @default.
• W2024602110 hasConceptScore W2024602110C54355233 @default.

• next