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• W2024605178 abstract "Common fragile sites (CFS) are large, genomically unstable regions, which are hot-spots for deletions and other alterations, especially in cancer cells. Several have been shown to contain genes that span large genomic regions, such as FHIT (1.5 Mb), WWOX (1.0 Mb), GRID2 (1.36 Mb), PARK2 (1.3 Mb), and RORA (730 kb). These genes are frequently inactivated in multiple different cancers, and FHIT and WWOX are shown to function as tumor suppressors. The disabled-1 gene (DAB1) is one of the human homologs of the Drosophila disabled locus, which in mammals is involved in neuronal migration and lamination in the developing cerebral cortex. Mice DAB1 inactivation results in the neurological mutant Scrambler, having similarities to mice with the inactivation of PARK2 (Quaker), GRID2 (Lurcher), and RORA (Staggerer). We were interested in whether DAB1 was another large CFS gene that could have cancer development importance. We demonstrated here that the human DAB1 gene (spanning 1.25 Mb) mapped within FRA1B CFS region on chromosomal band 1p32.2. Real-time RT-PCR analysis revealed that the expression level of DAB1 was decreased in many human cancer samples, including primary tumor tissues and cancer-derived cell lines, from several different cancers, especially in brain and endometrial cancer. Additionally, the introduction of an over-expression DAB1 plasmid into two different cell lines, having insignificant endogenous DAB1 expression, resulted in decreased cell growth. In summary, DAB1 is another gene that resides within an unstable CFS region and might play a role in human tumorigenesis. These data may provide further linkage between neurological development and cancer." @default.
• W2024605178 created "2016-06-24" @default.
• W2024605178 creator A5017722354 @default.
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• W2024605178 creator A5076763078 @default.
• W2024605178 creator A5078239377 @default.
• W2024605178 date "2007-01-01" @default.
• W2024605178 modified "2023-09-26" @default.
• W2024605178 title "Disabled-1 is a large common fragile site gene, inactivated in multiple cancers" @default.
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• W2024605178 cites W1808157780 @default.
• W2024605178 cites W1877873625 @default.
• W2024605178 cites W1964643678 @default.
• W2024605178 cites W1965558300 @default.
• W2024605178 cites W1965812209 @default.
• W2024605178 cites W1967743500 @default.
• W2024605178 cites W1974993967 @default.
• W2024605178 cites W1977001542 @default.
• W2024605178 cites W1984702583 @default.
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• W2024605178 cites W1988013635 @default.
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• W2024605178 cites W1992294260 @default.
• W2024605178 cites W2006729877 @default.
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• W2024605178 cites W2008025085 @default.
• W2024605178 cites W2014872373 @default.
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• W2024605178 cites W2037186153 @default.
• W2024605178 cites W2046807427 @default.
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• W2024605178 cites W2088858763 @default.
• W2024605178 cites W2088902082 @default.
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• W2024605178 doi "https://doi.org/10.1002/gcc.20519" @default.
• W2024605178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18008369" @default.
• W2024605178 hasPublicationYear "2007" @default.
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