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• W2024606444 endingPage "75" @default.
• W2024606444 startingPage "68" @default.
• W2024606444 abstract "In 1977 Sen, Tarazi and Bumpus in a brief article in Cardiovascular Research discussed the variable effects obtained with anti-hypertensive therapy on cardiac hypertrophy and its regression [1]. Having the aim of intervening with medical treatment on cardiac hypertrophy the authors attained results quite different from the expected one. Although this event is very common in research the authors were able to take advantage from the discrepancy suggesting new hypotheses, possible explanations and innovating conclusions. They found that in spontaneous hypertensive rats (SHR), an animal model that mimics essential hypertension in humans, the vasodilator α-methyldopa was able to reduce blood pressure, renin activity and reverse cardiac hypertrophy, whereas minoxidil another vasodilator reduced blood pressure, increased heart weight and renin activity. Finally, beta blockade not affecting blood pressure, reduced cardiac mass and renin activity. These results highlighted the uncertainty in the relation between cardiac hypertrophy, arterial blood pressure levels and renin, implying that blood pressure ‘may not be the sole factor for the development and reversal of cardiac hypertrophy’. Today, more than 20 years after the publication of this article there is evidence that these ideas are of relevance and extremely important to understanding the mechanisms involved in the development and progression of cardiac hypertrophy. This is also demonstrated by the large number of quotations of this article in the following years.In this review the results obtained in human and some animal models of cardiac hypertrophy will be summarized in the attempt to illustrate the complexity of the phenomena implicated in the hypertrophy of the heart and the evolution of the process toward dysfunction and failure. Furthermore, some new attempts to modify the consequence of myocardial hypertrophy or to prevent myocyte cell loss will be also examined to document the difficulties that we are still facing more than 20 …" @default.
• W2024606444 created "2016-06-24" @default.
• W2024606444 creator A5010020448 @default.
• W2024606444 creator A5045373094 @default.
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• W2024606444 creator A5076031173 @default.
• W2024606444 creator A5084986268 @default.
• W2024606444 creator A5086254990 @default.
• W2024606444 date "2000-01-01" @default.
• W2024606444 modified "2023-09-25" @default.
• W2024606444 title "Recent advances in cardiac hypertrophy" @default.
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