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• W2024610143 abstract "PurposeMultiple studies have assessed the prognostic value of peak oxygen consumption (VO2max) and LV function separately in dilated cardiomyopathy (DCM) but none have incorporated metrics for both LV strain and peak VO2. The aim of the study is to evaluate the added prognostic information of LV strain combined with cardiopulmonary exercise testing (CPET) responses in patients with DCM.Methods207 consecutive patients with DCM undergoing CPET and echocardiography within 1 month of each other were included in the study. Medical charts were reviewed and the recently validated MAGGIC-score (age, sex, BMI, NYHA, EF, creatinine, smoking, diabetes, COPD, medication, duration of disease) was calculated. Comprehensive echocardiographic evaluations were performed including measures of both right and left global longitudinal strain. A composite outcome of including death, heart transplant, LVAD and heart failure hospitalization was the primary endpoint.ResultsThe sample was 65% male, mean age 47 ±13 yo, NYHA Class 2.4 ±0.9, LVEF 33%±13 and LV longitudinal strain was 10.6% ±4.5. Peak VO2 was 20.1 ±10 mL/kg/min, the VE/VCO2 slope was 30.3±6.1 and the MAGGIC-score was of 16.2 ± 6.8. Peak VO2 was significantly correlated with age (r=-0.46), sex (female r=-0.31), LV longitudinal strain (r=0.4), resting heart rate (r=-0.19) and Beta-blockers (r=-0.2). The VE/VCO2 slope was significantly correlated with age (r=0.13) LV longitudinal strain (r=-0.3) and indexed right atrial size (r=0.34). Seven patients were lost to FU and a total of 48 events occurred. In a model including MAGGIC-score, the predictive variables for cardiac events were: MAGGIC-score, p=0.003, Peak VO2, p=0.001 and indexed right atrium area, p=0.005. In a model excluding the MAGGIC-score predictors of events were: Peak-VO2, p=0.04, indexed RAA, p=0.001, LV longitudinal strain, p=0.005 and creatinine clearance, p=0.02.ConclusionPeak VO2 and RAA add incremental prognostic value to the MAGGIC-score for predicting events in DCM. PurposeMultiple studies have assessed the prognostic value of peak oxygen consumption (VO2max) and LV function separately in dilated cardiomyopathy (DCM) but none have incorporated metrics for both LV strain and peak VO2. The aim of the study is to evaluate the added prognostic information of LV strain combined with cardiopulmonary exercise testing (CPET) responses in patients with DCM. Multiple studies have assessed the prognostic value of peak oxygen consumption (VO2max) and LV function separately in dilated cardiomyopathy (DCM) but none have incorporated metrics for both LV strain and peak VO2. The aim of the study is to evaluate the added prognostic information of LV strain combined with cardiopulmonary exercise testing (CPET) responses in patients with DCM. Methods207 consecutive patients with DCM undergoing CPET and echocardiography within 1 month of each other were included in the study. Medical charts were reviewed and the recently validated MAGGIC-score (age, sex, BMI, NYHA, EF, creatinine, smoking, diabetes, COPD, medication, duration of disease) was calculated. Comprehensive echocardiographic evaluations were performed including measures of both right and left global longitudinal strain. A composite outcome of including death, heart transplant, LVAD and heart failure hospitalization was the primary endpoint. 207 consecutive patients with DCM undergoing CPET and echocardiography within 1 month of each other were included in the study. Medical charts were reviewed and the recently validated MAGGIC-score (age, sex, BMI, NYHA, EF, creatinine, smoking, diabetes, COPD, medication, duration of disease) was calculated. Comprehensive echocardiographic evaluations were performed including measures of both right and left global longitudinal strain. A composite outcome of including death, heart transplant, LVAD and heart failure hospitalization was the primary endpoint. ResultsThe sample was 65% male, mean age 47 ±13 yo, NYHA Class 2.4 ±0.9, LVEF 33%±13 and LV longitudinal strain was 10.6% ±4.5. Peak VO2 was 20.1 ±10 mL/kg/min, the VE/VCO2 slope was 30.3±6.1 and the MAGGIC-score was of 16.2 ± 6.8. Peak VO2 was significantly correlated with age (r=-0.46), sex (female r=-0.31), LV longitudinal strain (r=0.4), resting heart rate (r=-0.19) and Beta-blockers (r=-0.2). The VE/VCO2 slope was significantly correlated with age (r=0.13) LV longitudinal strain (r=-0.3) and indexed right atrial size (r=0.34). Seven patients were lost to FU and a total of 48 events occurred. In a model including MAGGIC-score, the predictive variables for cardiac events were: MAGGIC-score, p=0.003, Peak VO2, p=0.001 and indexed right atrium area, p=0.005. In a model excluding the MAGGIC-score predictors of events were: Peak-VO2, p=0.04, indexed RAA, p=0.001, LV longitudinal strain, p=0.005 and creatinine clearance, p=0.02. The sample was 65% male, mean age 47 ±13 yo, NYHA Class 2.4 ±0.9, LVEF 33%±13 and LV longitudinal strain was 10.6% ±4.5. Peak VO2 was 20.1 ±10 mL/kg/min, the VE/VCO2 slope was 30.3±6.1 and the MAGGIC-score was of 16.2 ± 6.8. Peak VO2 was significantly correlated with age (r=-0.46), sex (female r=-0.31), LV longitudinal strain (r=0.4), resting heart rate (r=-0.19) and Beta-blockers (r=-0.2). The VE/VCO2 slope was significantly correlated with age (r=0.13) LV longitudinal strain (r=-0.3) and indexed right atrial size (r=0.34). Seven patients were lost to FU and a total of 48 events occurred. In a model including MAGGIC-score, the predictive variables for cardiac events were: MAGGIC-score, p=0.003, Peak VO2, p=0.001 and indexed right atrium area, p=0.005. In a model excluding the MAGGIC-score predictors of events were: Peak-VO2, p=0.04, indexed RAA, p=0.001, LV longitudinal strain, p=0.005 and creatinine clearance, p=0.02. ConclusionPeak VO2 and RAA add incremental prognostic value to the MAGGIC-score for predicting events in DCM. Peak VO2 and RAA add incremental prognostic value to the MAGGIC-score for predicting events in DCM." @default.
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• W2024610143 title "The Independent Predictive Value of Peak Oxygen Consumption, Left ventricular Strain and Atrial Remodelling in Patients With Dilated Cardiomyopathy" @default.
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