FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024621619> ?p ?o ?g. }

• W2024621619 endingPage "e44064" @default.
• W2024621619 startingPage "e44064" @default.
• W2024621619 abstract "Background Warfarin is a highly effective anticoagulant however its effectiveness relies on maintaining INR in therapeutic range. Finding the correct dose is difficult due to large inter-individual variability. Two genes, CYP2C9 and VKORC1, have been associated with this variability, leading to genotype-guided dosing tables in warfarin labeling. Nonetheless, it remains unclear how genotypic information should be used in practice. Navigating the literature to determine how genotype will influence warfarin response in a particular patient is difficult, due to significant variation in patient ethnicity, outcomes investigated, study design, and methodological rigor. Our systematic review was conducted to enable fair and accurate interpretation of which variants affect which outcomes, in which patients, and to what extent. Methodology/Principal Findings A comprehensive search strategy was applied and 117 studies included. Primary outcomes were stable dose, time to stable dose and bleeding events. Methodological quality was assessed using criteria of Jorgensen and Williamson and data synthesized in meta-analyses using advanced methods. Pooled effect estimates were significant in most ethnic groups for CYP2C9*3 and stable dose (mutant types requiring between 1.1(0.7–1.5) and 2.3 (1.6–3.0)mg/day). Effect estimates were also significant for VKORC1 and stable dose for most ethnicities, although direction differed between asians and non-asians (mutant types requiring between 0.8(0.4–1.3) and 1.5(1.1–1.8)mg/day more in asians and between 1.5(0.7–2.2) and 3.1(2.7–3.6)mg/day less in non-asians). Several studies were excluded due to inadequate data reporting. Assessing study quality highlighted significant variability in methodological rigor. Notably, there was significant evidence of selective reporting, of outcomes and analysis approaches. Conclusions/Significance Genetic associations with warfarin response vary between ethnicities. In order to achieve unbiased estimates in different populations, a high level of methodological rigor must be maintained and studies should report sufficient data to enable inclusion in meta-analyses. We propose minimum reporting requirements, suggest methodological guidelines and provide recommendations for reducing the risk of selective reporting." @default.
• W2024621619 created "2016-06-24" @default.
• W2024621619 creator A5006847944 @default.
• W2024621619 creator A5047395227 @default.
• W2024621619 creator A5047661674 @default.
• W2024621619 creator A5072801492 @default.
• W2024621619 creator A5079476800 @default.
• W2024621619 date "2012-08-29" @default.
• W2024621619 modified "2023-10-10" @default.
• W2024621619 title "Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis" @default.
• W2024621619 cites W1515782956 @default.
• W2024621619 cites W1517555081 @default.
• W2024621619 cites W1532066818 @default.
• W2024621619 cites W1578823824 @default.
• W2024621619 cites W1598602811 @default.
• W2024621619 cites W1601981977 @default.
• W2024621619 cites W1614927947 @default.
• W2024621619 cites W1913738350 @default.
• W2024621619 cites W1964334086 @default.
• W2024621619 cites W1966224670 @default.
• W2024621619 cites W1967796257 @default.
• W2024621619 cites W1968825981 @default.
• W2024621619 cites W1968983028 @default.
• W2024621619 cites W1969839955 @default.
• W2024621619 cites W1969840708 @default.
• W2024621619 cites W1972393846 @default.
• W2024621619 cites W1973268518 @default.
• W2024621619 cites W1973774410 @default.
• W2024621619 cites W1977280638 @default.
• W2024621619 cites W1978892904 @default.
• W2024621619 cites W1979357552 @default.
• W2024621619 cites W1979608570 @default.
• W2024621619 cites W1983000301 @default.
• W2024621619 cites W1988037592 @default.
• W2024621619 cites W1992259971 @default.
• W2024621619 cites W1993788823 @default.
• W2024621619 cites W1998269707 @default.
• W2024621619 cites W1998461499 @default.
• W2024621619 cites W1998664238 @default.
• W2024621619 cites W1999034569 @default.
• W2024621619 cites W2000828073 @default.
• W2024621619 cites W2001326588 @default.
• W2024621619 cites W2001411232 @default.
• W2024621619 cites W2005664643 @default.
• W2024621619 cites W2006566690 @default.
• W2024621619 cites W2006914590 @default.
• W2024621619 cites W2011045531 @default.
• W2024621619 cites W2011403103 @default.
• W2024621619 cites W2013156742 @default.
• W2024621619 cites W2013375415 @default.
• W2024621619 cites W2014181699 @default.
• W2024621619 cites W2015137389 @default.
• W2024621619 cites W2016935074 @default.
• W2024621619 cites W2017538702 @default.
• W2024621619 cites W2020539241 @default.
• W2024621619 cites W2020554169 @default.
• W2024621619 cites W2025144228 @default.
• W2024621619 cites W2025626547 @default.
• W2024621619 cites W2026420020 @default.
• W2024621619 cites W2026736116 @default.
• W2024621619 cites W2027036695 @default.
• W2024621619 cites W2028189243 @default.
• W2024621619 cites W2030007779 @default.
• W2024621619 cites W2032289591 @default.
• W2024621619 cites W2034633980 @default.
• W2024621619 cites W2035717626 @default.
• W2024621619 cites W2037171637 @default.
• W2024621619 cites W2037759951 @default.
• W2024621619 cites W2037963439 @default.
• W2024621619 cites W2038118250 @default.
• W2024621619 cites W2039500477 @default.
• W2024621619 cites W2039577410 @default.
• W2024621619 cites W2041501033 @default.
• W2024621619 cites W2042292509 @default.
• W2024621619 cites W2043674997 @default.
• W2024621619 cites W2047100625 @default.
• W2024621619 cites W2047193459 @default.
• W2024621619 cites W2048416680 @default.
• W2024621619 cites W2051372137 @default.
• W2024621619 cites W2054470297 @default.
• W2024621619 cites W2059587305 @default.
• W2024621619 cites W2061739968 @default.
• W2024621619 cites W2062293556 @default.
• W2024621619 cites W2063102214 @default.
• W2024621619 cites W2063545721 @default.
• W2024621619 cites W2065133143 @default.
• W2024621619 cites W2068476516 @default.
• W2024621619 cites W2068602483 @default.
• W2024621619 cites W2070284767 @default.
• W2024621619 cites W2070753488 @default.
• W2024621619 cites W2072026981 @default.
• W2024621619 cites W2078103904 @default.
• W2024621619 cites W2078517865 @default.
• W2024621619 cites W2079054758 @default.
• W2024621619 cites W2082461463 @default.
• W2024621619 cites W2084264788 @default.
• W2024621619 cites W2084868493 @default.
• W2024621619 cites W2085067513 @default.

• next