Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024623688> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2024623688 endingPage "S326" @default.
- W2024623688 startingPage "S317" @default.
- W2024623688 abstract "Platelet glycoprotein (GP) IIb-IIIa receptor antagonists are being used with increasing frequency in the settings of percutaneous coronary interventions and acute ischemic syndromes. The development of thrombocytopenia after GP IIb-IIIa blockade has been observed to some extent with all parenteral GP IIb-IIIa inhibitors studied to date and could potentially limit their effectiveness. The incidence and severity of thrombocytopenia has varied in large clinical trials with GP IIb-IIIa inhibitors, presumably as a consequence of the different structural and pharmacokinetic characteristics of the agents, the dose administered and duration of use, repetition of exposure, and the various drugs coadministered with these agents. Certain baseline characteristics may be predictive. In most cases, severe thrombocytopenia associated with the use of GP IIb-IIIa receptor antagonists was readily reversible with platelet transfusion and was not usually associated with major clinical sequelae. Although the exact mechanisms responsible for thrombocytopenia after GP IIb-IIIa blockade are poorly understood, an immune mechanism is suggested in which the binding of the antagonist to GP IIb-IIIa receptors leads to the exposure of ligand-induced binding sites recognized by preexisting or induced antibodies. Alternatively, the receptor-drug metabolite complex itself may induce an immune response. All patients receiving parenteral GP IIb-IIIa inhibitors should be monitored within 24 hours of initiation of therapy for the development of thrombocytopenia. An algorithm for the detection and management of thrombocytopenia after GP IIb-IIIa inhibitor therapy is proposed." @default.
- W2024623688 created "2016-06-24" @default.
- W2024623688 creator A5055052720 @default.
- W2024623688 creator A5083162965 @default.
- W2024623688 date "1999-10-01" @default.
- W2024623688 modified "2023-10-09" @default.
- W2024623688 title "Understanding thrombocytopenia and antigenicity with glycoprotein IIb-IIIa inhibitors" @default.
- W2024623688 cites W160180679 @default.
- W2024623688 cites W184991791 @default.
- W2024623688 cites W1963589960 @default.
- W2024623688 cites W1973995242 @default.
- W2024623688 cites W1979105454 @default.
- W2024623688 cites W2001707508 @default.
- W2024623688 cites W2009188243 @default.
- W2024623688 cites W2022311002 @default.
- W2024623688 cites W2026202162 @default.
- W2024623688 cites W2027265158 @default.
- W2024623688 cites W2037545303 @default.
- W2024623688 cites W2046705630 @default.
- W2024623688 cites W2052899600 @default.
- W2024623688 cites W2064739148 @default.
- W2024623688 cites W2068153038 @default.
- W2024623688 cites W2087305090 @default.
- W2024623688 cites W2092826927 @default.
- W2024623688 cites W2121964226 @default.
- W2024623688 cites W2136540192 @default.
- W2024623688 cites W2207113963 @default.
- W2024623688 cites W2230838014 @default.
- W2024623688 cites W2281862598 @default.
- W2024623688 cites W2313726388 @default.
- W2024623688 cites W2395313915 @default.
- W2024623688 cites W2402519077 @default.
- W2024623688 cites W2416986185 @default.
- W2024623688 cites W2913752260 @default.
- W2024623688 cites W3022148767 @default.
- W2024623688 cites W4230982479 @default.
- W2024623688 cites W4233930657 @default.
- W2024623688 cites W4237482550 @default.
- W2024623688 cites W4237892021 @default.
- W2024623688 cites W4242422342 @default.
- W2024623688 doi "https://doi.org/10.1053/hj.1999.v138.a100465" @default.
- W2024623688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10502237" @default.
- W2024623688 hasPublicationYear "1999" @default.
- W2024623688 type Work @default.
- W2024623688 sameAs 2024623688 @default.
- W2024623688 citedByCount "69" @default.
- W2024623688 countsByYear W20246236882012 @default.
- W2024623688 countsByYear W20246236882013 @default.
- W2024623688 countsByYear W20246236882014 @default.
- W2024623688 countsByYear W20246236882015 @default.
- W2024623688 countsByYear W20246236882016 @default.
- W2024623688 countsByYear W20246236882017 @default.
- W2024623688 countsByYear W20246236882019 @default.
- W2024623688 countsByYear W20246236882020 @default.
- W2024623688 crossrefType "journal-article" @default.
- W2024623688 hasAuthorship W2024623688A5055052720 @default.
- W2024623688 hasAuthorship W2024623688A5083162965 @default.
- W2024623688 hasBestOaLocation W20246236881 @default.
- W2024623688 hasConcept C126322002 @default.
- W2024623688 hasConcept C170493617 @default.
- W2024623688 hasConcept C203014093 @default.
- W2024623688 hasConcept C2777871224 @default.
- W2024623688 hasConcept C2778468042 @default.
- W2024623688 hasConcept C2780400711 @default.
- W2024623688 hasConcept C500558357 @default.
- W2024623688 hasConcept C71924100 @default.
- W2024623688 hasConcept C89560881 @default.
- W2024623688 hasConcept C98274493 @default.
- W2024623688 hasConceptScore W2024623688C126322002 @default.
- W2024623688 hasConceptScore W2024623688C170493617 @default.
- W2024623688 hasConceptScore W2024623688C203014093 @default.
- W2024623688 hasConceptScore W2024623688C2777871224 @default.
- W2024623688 hasConceptScore W2024623688C2778468042 @default.
- W2024623688 hasConceptScore W2024623688C2780400711 @default.
- W2024623688 hasConceptScore W2024623688C500558357 @default.
- W2024623688 hasConceptScore W2024623688C71924100 @default.
- W2024623688 hasConceptScore W2024623688C89560881 @default.
- W2024623688 hasConceptScore W2024623688C98274493 @default.
- W2024623688 hasIssue "4" @default.
- W2024623688 hasLocation W20246236881 @default.
- W2024623688 hasLocation W20246236882 @default.
- W2024623688 hasOpenAccess W2024623688 @default.
- W2024623688 hasPrimaryLocation W20246236881 @default.
- W2024623688 hasRelatedWork W1965040193 @default.
- W2024623688 hasRelatedWork W1994005296 @default.
- W2024623688 hasRelatedWork W2008337977 @default.
- W2024623688 hasRelatedWork W2009292691 @default.
- W2024623688 hasRelatedWork W2035951663 @default.
- W2024623688 hasRelatedWork W2051519978 @default.
- W2024623688 hasRelatedWork W2070509635 @default.
- W2024623688 hasRelatedWork W2074450625 @default.
- W2024623688 hasRelatedWork W2302245805 @default.
- W2024623688 hasRelatedWork W2810510606 @default.
- W2024623688 hasVolume "138" @default.
- W2024623688 isParatext "false" @default.
- W2024623688 isRetracted "false" @default.
- W2024623688 magId "2024623688" @default.
- W2024623688 workType "article" @default.