FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024629560> ?p ?o ?g. }

• W2024629560 endingPage "1054" @default.
• W2024629560 startingPage "1045" @default.
• W2024629560 abstract "Dual oxidases (DUOX) are conserved reduced nicotinamide adenine dinucleotide phosphate oxidases that produce H2O2 at the epithelial cell surface. The DUOX enzyme comprises the DUOX and DUOX maturation factor (DUOXA) subunits. Mammalian genomes encode 2 DUOX isoenzymes (DUOX1/DUOXA1 and DUOX2/DUOXA2). Expression of these genes is up-regulated during bacterial infections and chronic inflammatory diseases of the luminal gastrointestinal tract. The roles of DUOX in cellular interactions with microbes have not been determined in higher vertebrates.Mice with disruptions of Duoxa1 and Duoxa2 genes (Duoxa(-/-) mice) and control mice were infected with Helicobacter felis to create a model of Helicobacter pylori infection--the most common human chronic infection.Infection with H. felis induced expression of Duox2 and Duoxa2 in the stomachs of wild-type mice, and DUOX protein specifically localized to the apical surface of epithelial cells. H. felis colonized the mucus layer in the stomachs of Duoxa(-/-) mice to a greater extent than in control mice. The increased colonization persisted into the chronic phase of infection and correlated with an increased, yet ineffective, inflammatory response. H. felis colonization also was increased in Duoxa(+/-) mice, compared with controls. We observed reduced expression of the H2O2-inducible katA gene in H. felis that colonized Duoxa(-/-) mice, compared with that found in controls (P = .0002), indicating that Duox causes oxidative stress in these bacteria. In vitro, induction of oxidative defense by H. felis failed to prevent a direct bacteriostatic effect at sustained levels of H2O2 as low as 30 μmol/L.Based on studies of Duoxa(-/-) mice, the DUOX enzyme complex prevents gastric colonization by H. felis and the inflammatory response. These findings indicate the nonredundant function of epithelial production of H2O2 in restricting microbial colonization." @default.
• W2024629560 created "2016-06-24" @default.
• W2024629560 creator A5027591925 @default.
• W2024629560 creator A5042603101 @default.
• W2024629560 creator A5044407765 @default.
• W2024629560 creator A5050542983 @default.
• W2024629560 date "2013-11-01" @default.
• W2024629560 modified "2023-10-17" @default.
• W2024629560 title "Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter felis Infection and Inflammation in Mice" @default.
• W2024629560 cites W1831469664 @default.
• W2024629560 cites W1967225680 @default.
• W2024629560 cites W1970841988 @default.
• W2024629560 cites W1975230225 @default.
• W2024629560 cites W1975498928 @default.
• W2024629560 cites W1978148526 @default.
• W2024629560 cites W1982594309 @default.
• W2024629560 cites W2000179381 @default.
• W2024629560 cites W2002356275 @default.
• W2024629560 cites W2004016559 @default.
• W2024629560 cites W2007095789 @default.
• W2024629560 cites W2010726763 @default.
• W2024629560 cites W2014124696 @default.
• W2024629560 cites W2017486390 @default.
• W2024629560 cites W2035004193 @default.
• W2024629560 cites W2039452667 @default.
• W2024629560 cites W2044888716 @default.
• W2024629560 cites W2047043794 @default.
• W2024629560 cites W2052920675 @default.
• W2024629560 cites W2059511014 @default.
• W2024629560 cites W2064647551 @default.
• W2024629560 cites W2069463594 @default.
• W2024629560 cites W2072972271 @default.
• W2024629560 cites W2074519187 @default.
• W2024629560 cites W2079639127 @default.
• W2024629560 cites W2085968155 @default.
• W2024629560 cites W2089083496 @default.
• W2024629560 cites W2091834373 @default.
• W2024629560 cites W2101166931 @default.
• W2024629560 cites W2102549002 @default.
• W2024629560 cites W2112132467 @default.
• W2024629560 cites W2115492697 @default.
• W2024629560 cites W2115708356 @default.
• W2024629560 cites W2124223616 @default.
• W2024629560 cites W2124765964 @default.
• W2024629560 cites W2126888285 @default.
• W2024629560 cites W2129962921 @default.
• W2024629560 cites W2130649466 @default.
• W2024629560 cites W2134117303 @default.
• W2024629560 cites W2134581757 @default.
• W2024629560 cites W2144999905 @default.
• W2024629560 cites W2155083127 @default.
• W2024629560 cites W2155187715 @default.
• W2024629560 cites W2162624815 @default.
• W2024629560 cites W2170124733 @default.
• W2024629560 cites W2171398182 @default.
• W2024629560 cites W2172117086 @default.
• W2024629560 cites W2058884352 @default.
• W2024629560 doi "https://doi.org/10.1053/j.gastro.2013.07.011" @default.
• W2024629560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805753" @default.
• W2024629560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23860501" @default.
• W2024629560 hasPublicationYear "2013" @default.
• W2024629560 type Work @default.
• W2024629560 sameAs 2024629560 @default.
• W2024629560 citedByCount "87" @default.
• W2024629560 countsByYear W20246295602013 @default.
• W2024629560 countsByYear W20246295602014 @default.
• W2024629560 countsByYear W20246295602015 @default.
• W2024629560 countsByYear W20246295602016 @default.
• W2024629560 countsByYear W20246295602017 @default.
• W2024629560 countsByYear W20246295602018 @default.
• W2024629560 countsByYear W20246295602019 @default.
• W2024629560 countsByYear W20246295602020 @default.
• W2024629560 countsByYear W20246295602021 @default.
• W2024629560 countsByYear W20246295602022 @default.
• W2024629560 countsByYear W20246295602023 @default.
• W2024629560 crossrefType "journal-article" @default.
• W2024629560 hasAuthorship W2024629560A5027591925 @default.
• W2024629560 hasAuthorship W2024629560A5042603101 @default.
• W2024629560 hasAuthorship W2024629560A5044407765 @default.
• W2024629560 hasAuthorship W2024629560A5050542983 @default.
• W2024629560 hasBestOaLocation W20246295602 @default.
• W2024629560 hasConcept C104317684 @default.
• W2024629560 hasConcept C126322002 @default.
• W2024629560 hasConcept C153911025 @default.
• W2024629560 hasConcept C203014093 @default.
• W2024629560 hasConcept C2776347271 @default.
• W2024629560 hasConcept C2776409635 @default.
• W2024629560 hasConcept C2776914184 @default.
• W2024629560 hasConcept C2779904517 @default.
• W2024629560 hasConcept C2780832600 @default.
• W2024629560 hasConcept C54355233 @default.
• W2024629560 hasConcept C55493867 @default.
• W2024629560 hasConcept C71924100 @default.
• W2024629560 hasConcept C86803240 @default.
• W2024629560 hasConcept C89423630 @default.
• W2024629560 hasConceptScore W2024629560C104317684 @default.
• W2024629560 hasConceptScore W2024629560C126322002 @default.
• W2024629560 hasConceptScore W2024629560C153911025 @default.

• next