Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024631454> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2024631454 endingPage "481" @default.
- W2024631454 startingPage "473" @default.
- W2024631454 abstract "The preclinical evaluation of polymer biocompatibility is often performed using animal subcutaneous implant models. The choice of subcutaneous tissue as the implant site is due to a number of factors including simplicity of the surgery involved. Results from subcutaneous implants cannot necessarily be extrapolated to other tissues due to the differences in cellular composition of tissues. We have evaluated and compared the healing characteristics of expanded polytetrafluoroethylene (ePTFE) discs implanted in either subcutaneous tissue or epididymal fat pad tissue in rats. Following 3 and 5 weeks of implantation, the healing characteristics of discs were evaluated histologically with particular emphasis on tissue and polymer neovascularization. Implants placed in subcutaneous tissue exhibited limited formation of new microvascular elements within and directly in contact with the polymer, and the formation of an extensive fibrous capsule. In contrast, ePTFE implanted in the epididymal fat pads of rats exhibited extensive neovascularization of tissue surrounding the polymer, penetration of these microvascular cells into the graft interstices for distances ≤ 100 microns and no morphological evidence of a fibrous capsule. The rat epididymal fat pad provides an alternative tissue for polymer healing evaluations. Due to the extensive presence of fat in subcutaneous tissue in humans, we suggest the fat pad model provides a more relevant preclinical evaluation of the healing characteristics of polymers used clinically in anatomic positions which contain significant amounts of fat. © 1997 John Wiley & Sons, Inc." @default.
- W2024631454 created "2016-06-24" @default.
- W2024631454 creator A5008745378 @default.
- W2024631454 creator A5049839763 @default.
- W2024631454 creator A5072419465 @default.
- W2024631454 date "1997-06-15" @default.
- W2024631454 modified "2023-10-17" @default.
- W2024631454 title "Differential healing and neovascularization of ePTFE implants in subcutaneous versus adipose tissue" @default.
- W2024631454 cites W1505531015 @default.
- W2024631454 cites W1964337218 @default.
- W2024631454 cites W1977467901 @default.
- W2024631454 cites W1990635510 @default.
- W2024631454 cites W1997330806 @default.
- W2024631454 cites W2033125157 @default.
- W2024631454 cites W2055348294 @default.
- W2024631454 cites W2056725029 @default.
- W2024631454 cites W2059561150 @default.
- W2024631454 cites W2074705666 @default.
- W2024631454 cites W2312391348 @default.
- W2024631454 cites W4242622070 @default.
- W2024631454 doi "https://doi.org/10.1002/(sici)1097-4636(19970615)35:4<473::aid-jbm7>3.0.co;2-e" @default.
- W2024631454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9189825" @default.
- W2024631454 hasPublicationYear "1997" @default.
- W2024631454 type Work @default.
- W2024631454 sameAs 2024631454 @default.
- W2024631454 citedByCount "37" @default.
- W2024631454 countsByYear W20246314542014 @default.
- W2024631454 countsByYear W20246314542016 @default.
- W2024631454 countsByYear W20246314542017 @default.
- W2024631454 crossrefType "journal-article" @default.
- W2024631454 hasAuthorship W2024631454A5008745378 @default.
- W2024631454 hasAuthorship W2024631454A5049839763 @default.
- W2024631454 hasAuthorship W2024631454A5072419465 @default.
- W2024631454 hasConcept C105702510 @default.
- W2024631454 hasConcept C126322002 @default.
- W2024631454 hasConcept C136229726 @default.
- W2024631454 hasConcept C141071460 @default.
- W2024631454 hasConcept C171089720 @default.
- W2024631454 hasConcept C192562407 @default.
- W2024631454 hasConcept C2777300098 @default.
- W2024631454 hasConcept C2778271429 @default.
- W2024631454 hasConcept C2778778583 @default.
- W2024631454 hasConcept C2780394083 @default.
- W2024631454 hasConcept C2781411149 @default.
- W2024631454 hasConcept C49892992 @default.
- W2024631454 hasConcept C59822182 @default.
- W2024631454 hasConcept C71924100 @default.
- W2024631454 hasConcept C86803240 @default.
- W2024631454 hasConceptScore W2024631454C105702510 @default.
- W2024631454 hasConceptScore W2024631454C126322002 @default.
- W2024631454 hasConceptScore W2024631454C136229726 @default.
- W2024631454 hasConceptScore W2024631454C141071460 @default.
- W2024631454 hasConceptScore W2024631454C171089720 @default.
- W2024631454 hasConceptScore W2024631454C192562407 @default.
- W2024631454 hasConceptScore W2024631454C2777300098 @default.
- W2024631454 hasConceptScore W2024631454C2778271429 @default.
- W2024631454 hasConceptScore W2024631454C2778778583 @default.
- W2024631454 hasConceptScore W2024631454C2780394083 @default.
- W2024631454 hasConceptScore W2024631454C2781411149 @default.
- W2024631454 hasConceptScore W2024631454C49892992 @default.
- W2024631454 hasConceptScore W2024631454C59822182 @default.
- W2024631454 hasConceptScore W2024631454C71924100 @default.
- W2024631454 hasConceptScore W2024631454C86803240 @default.
- W2024631454 hasIssue "4" @default.
- W2024631454 hasLocation W20246314541 @default.
- W2024631454 hasLocation W20246314542 @default.
- W2024631454 hasOpenAccess W2024631454 @default.
- W2024631454 hasPrimaryLocation W20246314541 @default.
- W2024631454 hasRelatedWork W1974950787 @default.
- W2024631454 hasRelatedWork W2013311974 @default.
- W2024631454 hasRelatedWork W2048604637 @default.
- W2024631454 hasRelatedWork W2073109206 @default.
- W2024631454 hasRelatedWork W2143040158 @default.
- W2024631454 hasRelatedWork W2357652707 @default.
- W2024631454 hasRelatedWork W2358162314 @default.
- W2024631454 hasRelatedWork W2365313273 @default.
- W2024631454 hasRelatedWork W2401628417 @default.
- W2024631454 hasRelatedWork W2781477804 @default.
- W2024631454 hasVolume "35" @default.
- W2024631454 isParatext "false" @default.
- W2024631454 isRetracted "false" @default.
- W2024631454 magId "2024631454" @default.
- W2024631454 workType "article" @default.