FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024632135> ?p ?o ?g. }

• W2024632135 endingPage "e1005189" @default.
• W2024632135 startingPage "e1005189" @default.
• W2024632135 abstract "Meiotic recombination is a fundamental cellular process, with important consequences for evolution and genome integrity. However, we know little about how recombination rates vary across the genomes of most species and the molecular and evolutionary determinants of this variation. The honeybee, Apis mellifera, has extremely high rates of meiotic recombination, although the evolutionary causes and consequences of this are unclear. Here we use patterns of linkage disequilibrium in whole genome resequencing data from 30 diploid honeybees to construct a fine-scale map of rates of crossing over in the genome. We find that, in contrast to vertebrate genomes, the recombination landscape is not strongly punctate. Crossover rates strongly correlate with levels of genetic variation, but not divergence, which indicates a pervasive impact of selection on the genome. Germ-line methylated genes have reduced crossover rate, which could indicate a role of methylation in suppressing recombination. Controlling for the effects of methylation, we do not infer a strong association between gene expression patterns and recombination. The site frequency spectrum is strongly skewed from neutral expectations in honeybees: rare variants are dominated by AT-biased mutations, whereas GC-biased mutations are found at higher frequencies, indicative of a major influence of GC-biased gene conversion (gBGC), which we infer to generate an allele fixation bias 5 – 50 times the genomic average estimated in humans. We uncover further evidence that this repair bias specifically affects transitions and favours fixation of CpG sites. Recombination, via gBGC, therefore appears to have profound consequences on genome evolution in honeybees and interferes with the process of natural selection. These findings have important implications for our understanding of the forces driving molecular evolution." @default.
• W2024632135 created "2016-06-24" @default.
• W2024632135 creator A5054940859 @default.
• W2024632135 creator A5066034924 @default.
• W2024632135 creator A5087265755 @default.
• W2024632135 date "2015-04-22" @default.
• W2024632135 modified "2023-09-30" @default.
• W2024632135 title "Extreme Recombination Frequencies Shape Genome Variation and Evolution in the Honeybee, Apis mellifera" @default.
• W2024632135 cites W1963756058 @default.
• W2024632135 cites W1963998725 @default.
• W2024632135 cites W1964558095 @default.
• W2024632135 cites W1964797108 @default.
• W2024632135 cites W1967686316 @default.
• W2024632135 cites W1969461149 @default.
• W2024632135 cites W1969575610 @default.
• W2024632135 cites W1970283686 @default.
• W2024632135 cites W1974440260 @default.
• W2024632135 cites W1978025281 @default.
• W2024632135 cites W1979612448 @default.
• W2024632135 cites W1982906065 @default.
• W2024632135 cites W1984198684 @default.
• W2024632135 cites W1986196866 @default.
• W2024632135 cites W1987882116 @default.
• W2024632135 cites W1988834465 @default.
• W2024632135 cites W1992733095 @default.
• W2024632135 cites W1993093370 @default.
• W2024632135 cites W1993968374 @default.
• W2024632135 cites W1995148706 @default.
• W2024632135 cites W2000687405 @default.
• W2024632135 cites W2004391041 @default.
• W2024632135 cites W2005739865 @default.
• W2024632135 cites W2014078041 @default.
• W2024632135 cites W2016162945 @default.
• W2024632135 cites W2021739416 @default.
• W2024632135 cites W2026059246 @default.
• W2024632135 cites W2028242674 @default.
• W2024632135 cites W2031249741 @default.
• W2024632135 cites W2033461532 @default.
• W2024632135 cites W2042687932 @default.
• W2024632135 cites W2046720335 @default.
• W2024632135 cites W2047657819 @default.
• W2024632135 cites W2050457347 @default.
• W2024632135 cites W2054716800 @default.
• W2024632135 cites W2055742349 @default.
• W2024632135 cites W2064214354 @default.
• W2024632135 cites W2064296221 @default.
• W2024632135 cites W2069929819 @default.
• W2024632135 cites W2082967637 @default.
• W2024632135 cites W2085231911 @default.
• W2024632135 cites W2086327778 @default.
• W2024632135 cites W2088156872 @default.
• W2024632135 cites W2091835941 @default.
• W2024632135 cites W2093926676 @default.
• W2024632135 cites W2095434945 @default.
• W2024632135 cites W2096818703 @default.
• W2024632135 cites W2097233732 @default.
• W2024632135 cites W2099701655 @default.
• W2024632135 cites W2100238259 @default.
• W2024632135 cites W2102507175 @default.
• W2024632135 cites W2103677370 @default.
• W2024632135 cites W2105324108 @default.
• W2024632135 cites W2105817668 @default.
• W2024632135 cites W2108888124 @default.
• W2024632135 cites W2109947766 @default.
• W2024632135 cites W2112814626 @default.
• W2024632135 cites W2114493739 @default.
• W2024632135 cites W2117123843 @default.
• W2024632135 cites W2118020384 @default.
• W2024632135 cites W2121043033 @default.
• W2024632135 cites W2126204254 @default.
• W2024632135 cites W2126334905 @default.
• W2024632135 cites W2129454675 @default.
• W2024632135 cites W2130382579 @default.
• W2024632135 cites W2131979324 @default.
• W2024632135 cites W2135576052 @default.
• W2024632135 cites W2135607040 @default.
• W2024632135 cites W2143887498 @default.
• W2024632135 cites W2144214207 @default.
• W2024632135 cites W2147928140 @default.
• W2024632135 cites W2152758563 @default.
• W2024632135 cites W2155670634 @default.
• W2024632135 cites W2157009009 @default.
• W2024632135 cites W2157184850 @default.
• W2024632135 cites W2158714788 @default.
• W2024632135 cites W2159674456 @default.
• W2024632135 cites W2160563322 @default.
• W2024632135 cites W2162189733 @default.
• W2024632135 cites W2169225803 @default.
• W2024632135 cites W2170301165 @default.
• W2024632135 cites W2171377018 @default.
• W2024632135 cites W2171777347 @default.
• W2024632135 cites W2172187155 @default.
• W2024632135 cites W4232591682 @default.
• W2024632135 cites W4251304755 @default.
• W2024632135 doi "https://doi.org/10.1371/journal.pgen.1005189" @default.
• W2024632135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4406589" @default.
• W2024632135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25902173" @default.
• W2024632135 hasPublicationYear "2015" @default.

• next