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- W2024639098 abstract "Substrate specificity of SCF E3 ubiquitin ligases is thought to be determined by the F box protein subunit. Another component of SCF complexes is provided by members of the Roc1/Rbx1/Hrt1 gene family, which encode RING-H2 proteins. Drosophila contains three members of this gene family. We show that Roc1a mutant cells fail to proliferate. Further, while the F box protein Slimb is required for Cubitus interruptus (Ci) and Armadillo/beta-catenin (Arm) proteolysis, Roc1a mutant cells hyperaccumulate Ci but not Arm. This suggests that Slimb and Roc1a function in the same SCF complex to target Ci but that a different RING-H2 protein acts with Slimb to target Arm. Consequently, the identity of the Roc subunit may contribute to the selection of substrates by metazoan SCF complexes." @default.
- W2024639098 created "2016-06-24" @default.
- W2024639098 creator A5009651117 @default.
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- W2024639098 creator A5044158735 @default.
- W2024639098 creator A5069472220 @default.
- W2024639098 date "2002-06-01" @default.
- W2024639098 modified "2023-10-14" @default.
- W2024639098 title "Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase" @default.
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- W2024639098 doi "https://doi.org/10.1016/s1534-5807(02)00164-8" @default.
- W2024639098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12062088" @default.
- W2024639098 hasPublicationYear "2002" @default.
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