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- W2024642103 startingPage "69" @default.
- W2024642103 abstract "Undesirable host response is responsible for the surface induced thrombus generation, activation of the complement system and the inflammatory reactions by the blood-contacting biomaterials. The surface interaction of biomaterials with different blood components is thought to be the critical factor that dictates the host response to biomaterials. Surface engineering can be utilized as a method to enhance the biocompatibility and tailor the biological response to biomaterials. This review provides a brief account of various polymer brush based approaches used for biomaterials surface modification, both passive and bioactive, to make the material surfaces biocompatible and antibacterial. Initially we discuss the utilization of polymer brushes with different structure and chemistry as a novel strategy to design the surface non-fouling that passively prevent the subsequent biological responses. Further we explore the utility of different bioactive agents including peptides, carbohydrates and proteins which can be conjugated the polymer brush to make the surface actively interact with the body and modulate the host response. A number of such avenues have also been explored in this review." @default.
- W2024642103 created "2016-06-24" @default.
- W2024642103 creator A5001822496 @default.
- W2024642103 creator A5021046299 @default.
- W2024642103 creator A5023669597 @default.
- W2024642103 creator A5067519340 @default.
- W2024642103 date "2014-12-01" @default.
- W2024642103 modified "2023-10-07" @default.
- W2024642103 title "Engineering biomaterials surfaces to modulate the host response" @default.
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