FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024644009> ?p ?o ?g. }

• W2024644009 endingPage "433" @default.
• W2024644009 startingPage "426" @default.
• W2024644009 abstract "The aim of this study is to determine and identify the possible molecular mechanisms of anti-cancer effect of rhubarb under the physiologically achievable concentrations by using an ex vivo approach. Rats were orally administered rhubarb decoction and then serum metabolites were extracted, prepared and characterized to assay for the following in vitro study. The MTT assay, zymography analysis, wound healing assay, RT-PCR, and Western blot analysis were used to reveal molecular events of rhubarb metabolites in this study. Experimental metastasis model was used to investigate the in vivo anti-metastatic efficacy of rhubarb. Our results demonstrated that cell line mobility was strongly inhibited and the enzymatic activity of MMP-2 decreased following culture with the rhubarb serum metabolite in human lung adenocarcinoma A549 cells. Further experiments demonstrated that the downregulation of MMP-2 enzymatic activity act through both transcriptional and post-translational mechanisms. NF-κB/c-Jun and uPA were observed involving in the inhibition of MMP-2 transcription and post-translational modification, respectively, in A549 cells treated with rhubarb serum metabolite. Further animal experiments demonstrated a significant reduction in lung metastatic colonies in rhubarb-treated mice, suggesting that rhubarb contain enriched active components that block cancer metastasis. Our studies, both in vitro and in vivo, clearly demonstrated the anti-tumor effect of rhubarb in an experimental setting of achievable physiological concentrations and also provide possible molecular mechanisms of anti-metastatic mechanisms by rhubarb treatment." @default.
• W2024644009 created "2016-06-24" @default.
• W2024644009 creator A5003805332 @default.
• W2024644009 creator A5010232119 @default.
• W2024644009 creator A5044055404 @default.
• W2024644009 creator A5047435191 @default.
• W2024644009 creator A5055657360 @default.
• W2024644009 creator A5073324646 @default.
• W2024644009 date "2011-01-01" @default.
• W2024644009 modified "2023-09-27" @default.
• W2024644009 title "Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: An ex vivo approach" @default.
• W2024644009 cites W1604744894 @default.
• W2024644009 cites W1649424423 @default.
• W2024644009 cites W1853643611 @default.
• W2024644009 cites W1895814476 @default.
• W2024644009 cites W1966521182 @default.
• W2024644009 cites W1969801754 @default.
• W2024644009 cites W1976725370 @default.
• W2024644009 cites W1979390430 @default.
• W2024644009 cites W1990850715 @default.
• W2024644009 cites W1996315798 @default.
• W2024644009 cites W2010666032 @default.
• W2024644009 cites W2016584233 @default.
• W2024644009 cites W2033021780 @default.
• W2024644009 cites W2044924927 @default.
• W2024644009 cites W2048852504 @default.
• W2024644009 cites W2049220062 @default.
• W2024644009 cites W2051347744 @default.
• W2024644009 cites W2054117787 @default.
• W2024644009 cites W2054526986 @default.
• W2024644009 cites W2058380564 @default.
• W2024644009 cites W2063928578 @default.
• W2024644009 cites W2068872058 @default.
• W2024644009 cites W2071021121 @default.
• W2024644009 cites W2072271791 @default.
• W2024644009 cites W2074745469 @default.
• W2024644009 cites W2078950638 @default.
• W2024644009 cites W2086812549 @default.
• W2024644009 cites W2093213790 @default.
• W2024644009 cites W2095847870 @default.
• W2024644009 cites W2104692426 @default.
• W2024644009 cites W2113140652 @default.
• W2024644009 cites W2121836743 @default.
• W2024644009 cites W2124572106 @default.
• W2024644009 cites W2130028558 @default.
• W2024644009 cites W2133896679 @default.
• W2024644009 cites W2150106457 @default.
• W2024644009 cites W2154401382 @default.
• W2024644009 cites W2154806033 @default.
• W2024644009 cites W2158862003 @default.
• W2024644009 cites W2164858484 @default.
• W2024644009 cites W2328310528 @default.
• W2024644009 cites W4242893894 @default.
• W2024644009 doi "https://doi.org/10.1016/j.jep.2010.10.020" @default.
• W2024644009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20970489" @default.
• W2024644009 hasPublicationYear "2011" @default.
• W2024644009 type Work @default.
• W2024644009 sameAs 2024644009 @default.
• W2024644009 citedByCount "32" @default.
• W2024644009 countsByYear W20246440092012 @default.
• W2024644009 countsByYear W20246440092013 @default.
• W2024644009 countsByYear W20246440092014 @default.
• W2024644009 countsByYear W20246440092015 @default.
• W2024644009 countsByYear W20246440092016 @default.
• W2024644009 countsByYear W20246440092017 @default.
• W2024644009 countsByYear W20246440092018 @default.
• W2024644009 countsByYear W20246440092019 @default.
• W2024644009 countsByYear W20246440092020 @default.
• W2024644009 countsByYear W20246440092021 @default.
• W2024644009 countsByYear W20246440092022 @default.
• W2024644009 countsByYear W20246440092023 @default.
• W2024644009 crossrefType "journal-article" @default.
• W2024644009 hasAuthorship W2024644009A5003805332 @default.
• W2024644009 hasAuthorship W2024644009A5010232119 @default.
• W2024644009 hasAuthorship W2024644009A5044055404 @default.
• W2024644009 hasAuthorship W2024644009A5047435191 @default.
• W2024644009 hasAuthorship W2024644009A5055657360 @default.
• W2024644009 hasAuthorship W2024644009A5073324646 @default.
• W2024644009 hasConcept C104317684 @default.
• W2024644009 hasConcept C121608353 @default.
• W2024644009 hasConcept C150903083 @default.
• W2024644009 hasConcept C185592680 @default.
• W2024644009 hasConcept C202751555 @default.
• W2024644009 hasConcept C207001950 @default.
• W2024644009 hasConcept C26291073 @default.
• W2024644009 hasConcept C2776415932 @default.
• W2024644009 hasConcept C2777477808 @default.
• W2024644009 hasConcept C2779013556 @default.
• W2024644009 hasConcept C2780783641 @default.
• W2024644009 hasConcept C54355233 @default.
• W2024644009 hasConcept C55493867 @default.
• W2024644009 hasConcept C81729549 @default.
• W2024644009 hasConcept C86803240 @default.
• W2024644009 hasConcept C98274493 @default.
• W2024644009 hasConceptScore W2024644009C104317684 @default.
• W2024644009 hasConceptScore W2024644009C121608353 @default.
• W2024644009 hasConceptScore W2024644009C150903083 @default.
• W2024644009 hasConceptScore W2024644009C185592680 @default.

• next