FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024644137> ?p ?o ?g. }

• W2024644137 endingPage "88" @default.
• W2024644137 startingPage "82" @default.
• W2024644137 abstract "High levels of cardiac troponin T, measured by a highly sensitive assay (hs-cTnT), are strongly associated with incident coronary heart disease and heart failure. To date, no large-scale genome-wide association study of hs-cTnT has been reported. We sought to identify novel genetic variants that are associated with hs-cTnT levels.We performed a genome-wide association in 9491 European Americans and 2053 blacks free of coronary heart disease and heart failure from 2 prospective cohorts: the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Genome-wide association studies were conducted in each study and race stratum. Fixed-effect meta-analyses combined the results of linear regression from 2 cohorts within each race stratum and then across race strata to produce overall estimates and probability values. The meta-analysis identified a significant association at chromosome 8q13 (rs10091374; P=9.06×10(-9)) near the nuclear receptor coactivator 2 (NCOA2) gene. Overexpression of NCOA2 can be detected in myoblasts. An additional analysis using logistic regression and the clinically motivated 99th percentile cut point detected a significant association at 1q32 (rs12564445; P=4.73×10(-8)) in the gene TNNT2, which encodes the cardiac troponin T protein itself. The hs-cTnT-associated single-nucleotide polymorphisms were not associated with coronary heart disease in a large case-control study, but rs12564445 was significantly associated with incident heart failure in Atherosclerosis Risk in Communities Study European Americans (hazard ratio=1.16; P=0.004).We identified 2 loci, near NCOA2 and in the TNNT2 gene, at which variation was significantly associated with hs-cTnT levels. Further use of the new assay should enable replication of these results." @default.
• W2024644137 created "2016-06-24" @default.
• W2024644137 creator A5000636208 @default.
• W2024644137 creator A5002821639 @default.
• W2024644137 creator A5006663312 @default.
• W2024644137 creator A5028907710 @default.
• W2024644137 creator A5040642674 @default.
• W2024644137 creator A5040770914 @default.
• W2024644137 creator A5044048476 @default.
• W2024644137 creator A5048938940 @default.
• W2024644137 creator A5052604218 @default.
• W2024644137 creator A5063972278 @default.
• W2024644137 creator A5065660599 @default.
• W2024644137 creator A5071573513 @default.
• W2024644137 creator A5075741409 @default.
• W2024644137 creator A5077293985 @default.
• W2024644137 creator A5083705396 @default.
• W2024644137 creator A5084614356 @default.
• W2024644137 date "2013-02-01" @default.
• W2024644137 modified "2023-10-08" @default.
• W2024644137 title "Association of Genome-Wide Variation With Highly Sensitive Cardiac Troponin-T Levels in European Americans and Blacks" @default.
• W2024644137 cites W1976322287 @default.
• W2024644137 cites W1989197624 @default.
• W2024644137 cites W1995405806 @default.
• W2024644137 cites W1995697852 @default.
• W2024644137 cites W2008149232 @default.
• W2024644137 cites W2009826381 @default.
• W2024644137 cites W2038981426 @default.
• W2024644137 cites W2040635619 @default.
• W2024644137 cites W2068720423 @default.
• W2024644137 cites W2068986501 @default.
• W2024644137 cites W2076335162 @default.
• W2024644137 cites W2093951586 @default.
• W2024644137 cites W2098105324 @default.
• W2024644137 cites W2098148891 @default.
• W2024644137 cites W2101328404 @default.
• W2024644137 cites W2112848098 @default.
• W2024644137 cites W2119586206 @default.
• W2024644137 cites W2133816879 @default.
• W2024644137 cites W2138358802 @default.
• W2024644137 cites W2145438664 @default.
• W2024644137 cites W2146601153 @default.
• W2024644137 cites W2147571213 @default.
• W2024644137 cites W2157752701 @default.
• W2024644137 cites W2161197885 @default.
• W2024644137 cites W2161468919 @default.
• W2024644137 cites W2161676629 @default.
• W2024644137 cites W2313159400 @default.
• W2024644137 cites W2318201098 @default.
• W2024644137 cites W2556064842 @default.
• W2024644137 cites W4242416368 @default.
• W2024644137 doi "https://doi.org/10.1161/circgenetics.112.963058" @default.
• W2024644137 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3693561" @default.
• W2024644137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23247143" @default.
• W2024644137 hasPublicationYear "2013" @default.
• W2024644137 type Work @default.
• W2024644137 sameAs 2024644137 @default.
• W2024644137 citedByCount "23" @default.
• W2024644137 countsByYear W20246441372013 @default.
• W2024644137 countsByYear W20246441372014 @default.
• W2024644137 countsByYear W20246441372015 @default.
• W2024644137 countsByYear W20246441372016 @default.
• W2024644137 countsByYear W20246441372017 @default.
• W2024644137 countsByYear W20246441372018 @default.
• W2024644137 countsByYear W20246441372019 @default.
• W2024644137 countsByYear W20246441372020 @default.
• W2024644137 countsByYear W20246441372021 @default.
• W2024644137 countsByYear W20246441372022 @default.
• W2024644137 crossrefType "journal-article" @default.
• W2024644137 hasAuthorship W2024644137A5000636208 @default.
• W2024644137 hasAuthorship W2024644137A5002821639 @default.
• W2024644137 hasAuthorship W2024644137A5006663312 @default.
• W2024644137 hasAuthorship W2024644137A5028907710 @default.
• W2024644137 hasAuthorship W2024644137A5040642674 @default.
• W2024644137 hasAuthorship W2024644137A5040770914 @default.
• W2024644137 hasAuthorship W2024644137A5044048476 @default.
• W2024644137 hasAuthorship W2024644137A5048938940 @default.
• W2024644137 hasAuthorship W2024644137A5052604218 @default.
• W2024644137 hasAuthorship W2024644137A5063972278 @default.
• W2024644137 hasAuthorship W2024644137A5065660599 @default.
• W2024644137 hasAuthorship W2024644137A5071573513 @default.
• W2024644137 hasAuthorship W2024644137A5075741409 @default.
• W2024644137 hasAuthorship W2024644137A5077293985 @default.
• W2024644137 hasAuthorship W2024644137A5083705396 @default.
• W2024644137 hasAuthorship W2024644137A5084614356 @default.
• W2024644137 hasBestOaLocation W20246441371 @default.
• W2024644137 hasConcept C104317684 @default.
• W2024644137 hasConcept C106208931 @default.
• W2024644137 hasConcept C126322002 @default.
• W2024644137 hasConcept C135763542 @default.
• W2024644137 hasConcept C143998085 @default.
• W2024644137 hasConcept C144469398 @default.
• W2024644137 hasConcept C153209595 @default.
• W2024644137 hasConcept C164705383 @default.
• W2024644137 hasConcept C207103383 @default.
• W2024644137 hasConcept C2778198053 @default.
• W2024644137 hasConcept C44249647 @default.
• W2024644137 hasConcept C500558357 @default.

• next