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• W2024646386 abstract "<i>Background and Aims:</i> Stress can alter many aspects of the immune response, and many studies have been conducted on the effects of stress on inflammatory processes, but little is known about its influence on the resolution of inflammation in tissue homeostasis, which includes the clearance of apoptotic cells by macrophages in a non-phlogistic way. In the present study, we investigated the effect of acute cold stress on the phagocytosis of apoptotic cells by macrophages. <i>Methods:</i> Mice were submitted to acute cold stress (4°C for 4 h) and the capacity of peritoneal macrophages to phagocyte apoptotic thymocytes and to secrete anti-inflammatory cytokines was evaluated. Plasma corticosterone and catecholamine levels were investigated to assess their effect on the phagocytic capacity of macrophages in vitro. <i>Results:</i> We showed that acute cold stress decreases phagocytosis of apoptotic cells at the inflammatory site by lipopolysaccharide-activated macrophages but did not affect resting macrophages. The inhibitory effect on phagocytosis is accompanied by a reduced level of TGF-β and higher IL-10 secretion. After stress, plasma concentrations of corticosterone increased 6-fold, epinephrine 2-fold and norepinephrine 1.7-fold compared to control mice. In vitro experiments showed that the decrease in phagocytosis after stress could be attributed, at least in part, to the effects of corticosterone; epinephrine and norepinephrine had no effect. <i>Conclusions:</i> The current study shows that acute cold stress decreases phagocytosis of apoptotic cells from an inflammatory environment by macrophages, and this inhibition is mediated by the intracellular glucocorticoid receptor." @default.
• W2024646386 created "2016-06-24" @default.
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• W2024646386 creator A5041910989 @default.
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• W2024646386 date "2009-11-17" @default.
• W2024646386 modified "2023-09-26" @default.
• W2024646386 title "Effects of Acute Cold Stress on Phagocytosis of Apoptotic Cells: The Role of Corticosterone" @default.
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• W2024646386 doi "https://doi.org/10.1159/000258690" @default.
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