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• W2024648093 abstract "Abstract Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti‐inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high‐mobility group box ( HMGB )1 cascade signalling and inflammation in atopic dermatitis ( AD ) mouse model. AD ‐like lesion was induced by the application of house dust mite extract to the dorsal skin of NC /Nga transgenic mouse. After AD induction, quercetin (50 mg/kg, p.o) was administered daily for 2 weeks. We evaluated dermatitis severity, histopathological changes and changes in protein expression by Western blotting for HMGB 1, receptor for advanced glycation end products ( RAGE ), toll‐like receptor ( TLR )4, nuclear factor ( NF ) κ B, nuclear factor erythroid‐2‐related factor (Nrf)2, kelch‐like ECH ‐associated protein (Keap)1, extracellular signal‐regulated kinase ( ERK )1/2, cyclooxygenase ( COX )2, tumor necrosis factor ( TNF ) α , interleukin ( IL )‐1 β , IL ‐2R α and other inflammatory markers in the skin of AD mice. In addition, serum levels of T helper (Th) cytokines (interferon ( IFN ) γ , IL ‐4) were measured by enzyme‐linked immunosorbent assay. Quercetin treatment attenuated the development of AD ‐like skin lesions. Histological analysis showed that quercetin inhibited hyperkeratosis, parakeratosis, acanthosis, mast cells and infiltration of inflammatory cells. Furthermore, quercetin treatment downregulated cytoplasmic HMGB 1, RAGE , nuclear p‐ NF κ B, p‐ ERK 1/2, COX 2, TNF α , IL ‐1 β , IL ‐2R α , IFN γ and IL ‐4 and upregulated nuclear Nrf2. Our data demonstrated that the HMGB 1/ RAGE / NF κ B signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB 1/ RAGE / NF κ B signalling and induction of Nrf2 protein." @default.
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• W2024648093 date "2015-03-25" @default.
• W2024648093 modified "2023-10-17" @default.
• W2024648093 title "Modulation of HMGB1 translocation and RAGE/NF<i>κ</i>B cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice" @default.
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• W2024648093 doi "https://doi.org/10.1111/exd.12685" @default.
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