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• W2024649144 abstract "ABSTRACT Recently, we isolated a new thiopeptide antibiotic, TP-1161, from the fermentation broth of a marine actinomycete typed as a member of the genus Nocardiopsis . Here we report the identification, isolation, and analysis of the TP-1161 biosynthetic gene cluster from this species. The gene cluster was identified by mining a draft genome sequence using the predicted structural peptide sequence of TP-1161. Functional assignment of a ∼16-kb genomic region revealed 13 open reading frames proposed to constitute the TP-1161 biosynthetic locus. While the typical core set of thiopeptide modification enzymes contains one cyclodehydratase/dehydrogenase pair, paralogous genes predicted to encode additional cyclodehydratases and dehydrogenases were identified. Although attempts at heterologous expression of the TP-1161 gene cluster in Streptomyces coelicolor failed, its identity was confirmed through the targeted gene inactivation in the original host." @default.
• W2024649144 created "2016-06-24" @default.
• W2024649144 creator A5046302322 @default.
• W2024649144 creator A5060323178 @default.
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• W2024649144 date "2010-11-01" @default.
• W2024649144 modified "2023-09-27" @default.
• W2024649144 title "Isolation and Characterization of the Gene Cluster for Biosynthesis of the Thiopeptide Antibiotic TP-1161" @default.
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• W2024649144 doi "https://doi.org/10.1128/aem.01442-10" @default.
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