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- W2024649789 abstract "New 7-sulfonamido-3-benzazepines 3 are disclosed as 5-HT2C receptor agonists. Appropriate substitution of the amino group (R1R2N–) gave compounds that were potent 5-HT2C agonists with minimal activation of the 5-HT2A and 5-HT2B receptors. Furthermore, representative examples had excellent in vitro ADME properties and good selectivity over ion channel activity." @default.
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- W2024649789 date "2009-04-01" @default.
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- W2024649789 title "7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: Hit-to-lead optimization" @default.
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- W2024649789 doi "https://doi.org/10.1016/j.bmcl.2009.02.071" @default.
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