FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024650435> ?p ?o ?g. }

• W2024650435 endingPage "1245" @default.
• W2024650435 startingPage "1239" @default.
• W2024650435 abstract "The BRAF V600E (BRAF+) mutation activates the mitogen-activated protein kinase (MAPK/ERK) pathway and may confer an aggressive phenotype in papillary thyroid cancer (PTC). Clinically, the behavior of BRAF+ PTC, however, varies from an indolent to an aggressive course. SPRY2 is a negative feedback regulator of the MAPK/ERK pathway. We hypothesize that the level of SPRY2 expression contributes to MAPK/ERK pathway output and accounts for BRAF+ and clinical heterogeneity.A tissue microarray with BRAF-positive PTCs (BRAF+ PTCs) was constructed and analyzed for SPRY2 expression and MAPK/ERK output. Data were studied in the context of clinicopathologic factors to develop a risk stratification system predictive of tumor biology. SPRY2 function was studied by silencing SPRY2 in BRAF+ PTC cells. These cells were treated with MAPK/ERK pathway inhibitors and assessed for growth effects.BRAF+ PTCs with an intact MAPK/ERK feedback pathway do not exhibit lymph node metastases. BRAF+ PTCs with dysregulated feedback pathways have nodal metastasis. When SPRY2 is silenced, the BRAF+ PTC cells are significantly more sensitive to MAPK/ERK inhibition.PTC behavior likely is dependent on both the driver of the MAPK/ERK pathway and its regulatory feedback. When the feedback pathway is intact, the tumor phenotype seems to be less aggressive. This observation has direct and important clinical implications and may alter our treatment strategies." @default.
• W2024650435 created "2016-06-24" @default.
• W2024650435 creator A5014132604 @default.
• W2024650435 creator A5056698491 @default.
• W2024650435 creator A5075591922 @default.
• W2024650435 creator A5078858582 @default.
• W2024650435 creator A5085481193 @default.
• W2024650435 creator A5089379273 @default.
• W2024650435 date "2013-12-01" @default.
• W2024650435 modified "2023-10-17" @default.
• W2024650435 title "Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer" @default.
• W2024650435 cites W1795056021 @default.
• W2024650435 cites W1972850991 @default.
• W2024650435 cites W1977602504 @default.
• W2024650435 cites W1978802056 @default.
• W2024650435 cites W1982972087 @default.
• W2024650435 cites W1984732635 @default.
• W2024650435 cites W1995580330 @default.
• W2024650435 cites W2019683727 @default.
• W2024650435 cites W2021960304 @default.
• W2024650435 cites W2033882181 @default.
• W2024650435 cites W2038430229 @default.
• W2024650435 cites W2038683568 @default.
• W2024650435 cites W2041255253 @default.
• W2024650435 cites W2047051739 @default.
• W2024650435 cites W2055599569 @default.
• W2024650435 cites W2056212159 @default.
• W2024650435 cites W2062871120 @default.
• W2024650435 cites W2079563164 @default.
• W2024650435 cites W2086614146 @default.
• W2024650435 cites W2099516272 @default.
• W2024650435 cites W2101888941 @default.
• W2024650435 cites W2109544257 @default.
• W2024650435 cites W2139528774 @default.
• W2024650435 cites W2171379946 @default.
• W2024650435 doi "https://doi.org/10.1016/j.surg.2013.06.024" @default.
• W2024650435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4100696" @default.
• W2024650435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24094449" @default.
• W2024650435 hasPublicationYear "2013" @default.
• W2024650435 type Work @default.
• W2024650435 sameAs 2024650435 @default.
• W2024650435 citedByCount "8" @default.
• W2024650435 countsByYear W20246504352014 @default.
• W2024650435 countsByYear W20246504352015 @default.
• W2024650435 countsByYear W20246504352016 @default.
• W2024650435 countsByYear W20246504352017 @default.
• W2024650435 crossrefType "journal-article" @default.
• W2024650435 hasAuthorship W2024650435A5014132604 @default.
• W2024650435 hasAuthorship W2024650435A5056698491 @default.
• W2024650435 hasAuthorship W2024650435A5075591922 @default.
• W2024650435 hasAuthorship W2024650435A5078858582 @default.
• W2024650435 hasAuthorship W2024650435A5085481193 @default.
• W2024650435 hasAuthorship W2024650435A5089379273 @default.
• W2024650435 hasBestOaLocation W20246504352 @default.
• W2024650435 hasConcept C104317684 @default.
• W2024650435 hasConcept C119056186 @default.
• W2024650435 hasConcept C121608353 @default.
• W2024650435 hasConcept C126322002 @default.
• W2024650435 hasConcept C127716648 @default.
• W2024650435 hasConcept C184235292 @default.
• W2024650435 hasConcept C2776470698 @default.
• W2024650435 hasConcept C2779761222 @default.
• W2024650435 hasConcept C2781461381 @default.
• W2024650435 hasConcept C501734568 @default.
• W2024650435 hasConcept C502942594 @default.
• W2024650435 hasConcept C54355233 @default.
• W2024650435 hasConcept C57074206 @default.
• W2024650435 hasConcept C71924100 @default.
• W2024650435 hasConcept C86803240 @default.
• W2024650435 hasConcept C95444343 @default.
• W2024650435 hasConceptScore W2024650435C104317684 @default.
• W2024650435 hasConceptScore W2024650435C119056186 @default.
• W2024650435 hasConceptScore W2024650435C121608353 @default.
• W2024650435 hasConceptScore W2024650435C126322002 @default.
• W2024650435 hasConceptScore W2024650435C127716648 @default.
• W2024650435 hasConceptScore W2024650435C184235292 @default.
• W2024650435 hasConceptScore W2024650435C2776470698 @default.
• W2024650435 hasConceptScore W2024650435C2779761222 @default.
• W2024650435 hasConceptScore W2024650435C2781461381 @default.
• W2024650435 hasConceptScore W2024650435C501734568 @default.
• W2024650435 hasConceptScore W2024650435C502942594 @default.
• W2024650435 hasConceptScore W2024650435C54355233 @default.
• W2024650435 hasConceptScore W2024650435C57074206 @default.
• W2024650435 hasConceptScore W2024650435C71924100 @default.
• W2024650435 hasConceptScore W2024650435C86803240 @default.
• W2024650435 hasConceptScore W2024650435C95444343 @default.
• W2024650435 hasIssue "6" @default.
• W2024650435 hasLocation W20246504351 @default.
• W2024650435 hasLocation W20246504352 @default.
• W2024650435 hasLocation W20246504353 @default.
• W2024650435 hasLocation W20246504354 @default.
• W2024650435 hasOpenAccess W2024650435 @default.
• W2024650435 hasPrimaryLocation W20246504351 @default.
• W2024650435 hasRelatedWork W2014912105 @default.
• W2024650435 hasRelatedWork W2092948006 @default.
• W2024650435 hasRelatedWork W2179395367 @default.
• W2024650435 hasRelatedWork W2555072314 @default.
• W2024650435 hasRelatedWork W2886084647 @default.

• next