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• W2024650887 endingPage "2235" @default.
• W2024650887 startingPage "2223" @default.
• W2024650887 abstract "The ryanodine-sensitive calcium channels are pivotal to signal transduction and cell function in many cell types, including cardiac myocytes. In this paper a kinetic model is proposed for these channels. In the model there are two Ca regulatory sites on the channel protein, one positive and the other negative. Cytoplasmic Ca binds to these regulatory sites independently It is assumed that the binding of Ca to the positive site is a much faster process than binding to the negative site. At steady state, the channel opening as a function of the Ca concentration is a bell-shaped curve. The model predicts the adaptation of channels to constant Ca stimulus. When this model is applied to cardiac myocytes, it predicts excitability with respect to Ca perturbations, smoothly graded responses, and Ca oscillations in certain pathological circumstances. In a spatially distributed system, traveling Ca waves in individual myocytes exist under certain conditions. This model can also be applied to other systems where the ryanodine-sensitive channels have been identified." @default.
• W2024650887 created "2016-06-24" @default.
• W2024650887 creator A5047315609 @default.
• W2024650887 creator A5054877460 @default.
• W2024650887 date "1994-12-01" @default.
• W2024650887 modified "2023-09-27" @default.
• W2024650887 title "A model of calcium dynamics in cardiac myocytes based on the kinetics of ryanodine-sensitive calcium channels" @default.
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• W2024650887 doi "https://doi.org/10.1016/s0006-3495(94)80707-6" @default.
• W2024650887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1225606" @default.
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