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- W2024651013 abstract "Concentrations of 5-hydroxytryptamine (5-HT) in platelets were determined in 33 cluster headache patients (17 males) and in 34 migraine patients (16 males) outside attacks. The 5-HT uptake into platelets was measured and the kinetic constants V max and K m determined in 26 cluster patients (14 males) and in 30 migraine patients (13 males). Significantly lower 5-HT concentrations in whole blood were found in cluster headache and migraine patients than in 50 healthy controls (19 males). The V max and K m values of the 5-HT uptake were significantly lower in cluster headache and migraine patients compared with 22 healthy controls (9 males). The 5-HT concentrations and the kinetics of the 5-HT uptake did not differ between cluster headache and migraine. In healthy controls a significant positive correlation was found between the 5-HT uptake rate at 0.25 μM and K m but not in cluster headache and migraine patients. The 5-HT concentrations in whole blood correlated positively with V max and K m , respectively, in cluster headache and with K m in healthy controls but not with V max nor with K m in migraine. There was no obvious relation between the kinetics of platelet monoamine oxidase (MAO) and the 5-HT uptake except for an increased incidence of low V max of MAO and low K m of the 5-HT uptake in cluster headache. The kinetics of the 5-HT uptake was apparently not related to the state of migraine. The results indicate a possible constitutional trait in cluster headache and migraine expressed as low 5-HT concentrations in whole blood and low V max and K m of the 5-HT uptake into platelets." @default.
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- W2024651013 date "1985-03-01" @default.
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- W2024651013 title "Concentration and Uptake of 5-Hydroxytryptamine in Platelets from Cluster Headache and Migraine Patients" @default.
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- W2024651013 doi "https://doi.org/10.1046/j.1468-2982.1985.0501045.x" @default.
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