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- W2024654045 abstract "The Dictyostelium ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination." @default.
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- W2024654045 date "1991-06-01" @default.
- W2024654045 modified "2023-09-25" @default.
- W2024654045 title "Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium" @default.
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- W2024654045 doi "https://doi.org/10.1016/0092-8674(91)90550-i" @default.
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