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• W2024654416 startingPage "1621" @default.
• W2024654416 abstract "Cyclic AMP stimulates HCO3 secretion and Cl self-exchange in rabbit cortical collecting tubule. We found that varying peritubular [Cl] changed the Cl self-exchange rate with saturation kinetics (Km, 3-4 mM). HCO3 secretion also showed saturation kinetics as a function of mean luminal [Cl] (Km, 4-11 mM). Both Cl self-exchange and Cl-HCO3 exchange thus appear to be carrier-mediated. Addition/removal of basolateral HCO3 qualitatively changed Cl and HCO3 transport as expected for Cl-HCO3 exchange, but quantitatively changed Cl absorption more than HCO3 secretion. The diffusive Cl permeability and the transepithelial conductance in the presence of HCO3/CO2 and cAMP were higher than in their absence suggesting that HCO3/CO2 and cAMP together increase a conductive Cl pathway parallel to a 1:1 Cl-HCO3 exchanger. Thus, cAMP not only stimulates the overall process of anion exchange (probably by increasing an electroneutral exchanger and/or a series Cl conductance), but also stimulates a Cl conductance parallel to the exchange process." @default.
• W2024654416 created "2016-06-24" @default.
• W2024654416 creator A5054142504 @default.
• W2024654416 date "1986-12-01" @default.
• W2024654416 modified "2023-10-15" @default.
• W2024654416 title "Cyclic adenosine monophosphate-stimulated anion transport in rabbit cortical collecting duct. Kinetics, stoichiometry, and conductive pathways." @default.
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• W2024654416 doi "https://doi.org/10.1172/jci112755" @default.
• W2024654416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/423935" @default.
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