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- W2024654923 endingPage "156" @default.
- W2024654923 startingPage "145" @default.
- W2024654923 abstract "Primary brain tumours are difficult to manage clinically due to their abilities to invade adjacent tissue and infiltrate distant neuropil. These contribute to challenges in surgical management and also limit the effectiveness of radiotherapy. Despite initial responses to chemotherapy, most tumours become chemo-resistant, leading to relapse. Recent identification and isolation of brain cancer stem cells (BCSCs) have broadened our understanding of the molecular pathogenesis and potential Achilles' heel of brain tumours. BCSCs are thought to drive and propagate the tumour and therefore present an important target for further investigations. This review explores the history of the discovery of BCSCs and the evolving concept of cancer stem cells in neuro-oncology. We attempt to present a balanced view on the subject and also to update the readers on the molecular biology of BCSCs. Lastly, we outline the potential strategies to target BCSCs which will translate into specific and effective therapies for brain tumours." @default.
- W2024654923 created "2016-06-24" @default.
- W2024654923 creator A5044366354 @default.
- W2024654923 creator A5073718839 @default.
- W2024654923 creator A5090620792 @default.
- W2024654923 date "2012-03-01" @default.
- W2024654923 modified "2023-09-27" @default.
- W2024654923 title "Stem Cells in Brain Tumour Development and Therapy- Two-Sides of the Same Coin" @default.
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