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- W2024657575 abstract "The minimum oligosaccharide structure required for binding to the potent HIV-inactivating protein cyanovirin-N (CV-N) was determined by saturation-transfer difference (STD) NMR spectroscopy. Despite the low molecular mass of the protein (11 kDa), STD-NMR spectroscopy allowed the precise atomic mapping of the interactions between CV-N and various di- and trimannosides, substructures of Man-9, the predominant oligosaccharide on the HIV viral surface glycoprotein gp120. Contacts with mannosides containing the terminal Manα(1→2)Manα unit of Man-9 were observed, while (1→3)- and (1−6)-linked di- and trimannosides showed no interactions, demonstrating that the terminal Manα(1→2)Manα structure plays a key role in the interaction. Precise epitope mapping revealed that, for Manα(1→2)ManαOMe, Manα(1→2)Manα(1→3)ManαOMe, and Manα(1→2)Manα(1→6)ManαOMe, the protein is in close contact with H2, H3, and H4 of the nonreducing terminal mannose unit. In contrast, the STD-NMR spectrum of the CV-N/trisaccharide Manα(1→2)Manα(1→2)ManαOMe complex was markedly different, with resonances on all sugar units displaying equal enhancements, suggesting that CV-N is able to discriminate between the three structurally related trisaccharides." @default.
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- W2024657575 date "2004-10-13" @default.
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- W2024657575 title "Atomic Mapping of the Interactions between the Antiviral Agent Cyanovirin-N and Oligomannosides by Saturation-Transfer Difference NMR" @default.
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- W2024657575 doi "https://doi.org/10.1021/bi048676k" @default.
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