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• W2024658533 abstract "We have previously demonstrated that sera from dogs vaccinated with excreted/secreted antigens (ESA) of Leishmania infantum promastigotes (LiESAp) mainly recognized an immunodominant antigen of 54 kDa. An anti-LiESAp-specific IgG2 humoral response was observed and associated to Th1-type response in vaccinated dogs. This response was highly correlated with a long-lasting and strong LiESAp-vaccine protection toward L. infantum experimental infection. In addition, it was also shown that dogs from the vaccinated group developed a selective IgG2 response against an immunodominant antigen of 45 kDa of Leishmania amazonensis ESA promastigotes (LaESAp). In order to identify and characterize these immunodominant antigens, a mouse monoclonal antibody (mAb F5) was produced by immunization against LaESAp. It was found to recognize the major antigenic targets of both LaESAp and LiESAp. Analysis with mAb F5 of L. amazonensis amastigote and promastigote cDNA expression libraries enabled the identification of clones encoding proteins with significant structural homology to the promastigote surface antigens named PSA-2/gp-46. Among them, one clone presented a full-length cDNA and encoded a novel L. amazonensis protein of 38.6 kDa calculated molecular mass (LaPSA-38S) sharing an amino acid sequence consistent with that of the PSA polymorphic family and a N-terminal signal peptide, characteristic of a secreted protein. We then screened a L. infantum promastigote DNA cosmid library using a cDNA probe derived from the LaPSA-38S gene and identified a full-length clone of a novel excreted/secreted protein of L. infantum with a calculated molecular mass of 49.2 kDa and named LiPSA-50S. The fact that a significant immunological reactivity was observed against PSA, suggests that these newly identified proteins could have an important immunoregulatory influence on the immune response. This hypothesis is supported by the fact that (i) these proteins were naturally excreted/secreted by viable Leishmania promastigotes and amastigotes, and (ii) they are selectively recognized by vaccinated and protected dogs." @default.
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• W2024658533 date "2014-06-01" @default.
• W2024658533 modified "2023-10-09" @default.
• W2024658533 title "Identification and characterization of new Leishmania promastigote surface antigens, LaPSA-38S and LiPSA-50S, as major immunodominant excreted/secreted components of L. amazonensis and L. infantum" @default.
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• W2024658533 cites W1524872354 @default.
• W2024658533 cites W1526545436 @default.
• W2024658533 cites W1549845633 @default.
• W2024658533 cites W1761725949 @default.
• W2024658533 cites W1965202893 @default.
• W2024658533 cites W1969544897 @default.
• W2024658533 cites W1971644867 @default.
• W2024658533 cites W1974652725 @default.
• W2024658533 cites W1977433737 @default.
• W2024658533 cites W1980119393 @default.
• W2024658533 cites W1982661540 @default.
• W2024658533 cites W1983112451 @default.
• W2024658533 cites W1985477796 @default.
• W2024658533 cites W1987984717 @default.
• W2024658533 cites W1993944869 @default.
• W2024658533 cites W1998338339 @default.
• W2024658533 cites W2002615289 @default.
• W2024658533 cites W2013846378 @default.
• W2024658533 cites W2014073890 @default.
• W2024658533 cites W2014452639 @default.
• W2024658533 cites W2019296702 @default.
• W2024658533 cites W2022679761 @default.
• W2024658533 cites W2025122569 @default.
• W2024658533 cites W2030828147 @default.
• W2024658533 cites W2040468468 @default.
• W2024658533 cites W2046306052 @default.
• W2024658533 cites W2046685845 @default.
• W2024658533 cites W2050267572 @default.
• W2024658533 cites W2053895943 @default.
• W2024658533 cites W2056268983 @default.
• W2024658533 cites W2062590826 @default.
• W2024658533 cites W2064642543 @default.
• W2024658533 cites W2064842510 @default.
• W2024658533 cites W2066954635 @default.
• W2024658533 cites W2069313641 @default.
• W2024658533 cites W2071084118 @default.
• W2024658533 cites W2073120122 @default.
• W2024658533 cites W2074505948 @default.
• W2024658533 cites W2078852732 @default.
• W2024658533 cites W2080951625 @default.
• W2024658533 cites W2082417883 @default.
• W2024658533 cites W2084704653 @default.
• W2024658533 cites W2085062629 @default.
• W2024658533 cites W2087100451 @default.
• W2024658533 cites W2100837269 @default.
• W2024658533 cites W2101108802 @default.
• W2024658533 cites W2101173190 @default.
• W2024658533 cites W2104365617 @default.
• W2024658533 cites W2107689875 @default.
• W2024658533 cites W2107915297 @default.
• W2024658533 cites W2109753250 @default.
• W2024658533 cites W2113056926 @default.
• W2024658533 cites W2113517452 @default.
• W2024658533 cites W2128075712 @default.
• W2024658533 cites W2129222867 @default.
• W2024658533 cites W2132726621 @default.
• W2024658533 cites W2137600992 @default.
• W2024658533 cites W2152686523 @default.
• W2024658533 cites W2156690245 @default.
• W2024658533 cites W2159838688 @default.
• W2024658533 cites W2167122322 @default.
• W2024658533 cites W2169045546 @default.
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• W2024658533 cites W2171192872 @default.
• W2024658533 cites W2171530398 @default.
• W2024658533 cites W4293088719 @default.
• W2024658533 doi "https://doi.org/10.1016/j.meegid.2014.02.017" @default.
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• W2024658533 hasPublicationYear "2014" @default.
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