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- W2024661749 abstract "Replication of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) strains (containing the 41MetjLeuand215ThrjTyrmutations inreverse transcriptase [RT])was inhibitedto asignificantly greater extent by the combination of lamivudine and quinoxaline HBY 097 than by either drug alone or even fully suppressed by concomitant HBY097 and lamivudine administration at relatively lowconcentrations. The virus recovered after exposure to the drug combinations individually had acquired the 103 LysjArg, 138 GlujLys, 184 MetjIle, and 189 ValjIle mutations in the genetic zidovudine-resistance background of zidovudine-resistant HIV-1. These mutants retained marked sensitivity to HBY 097. The genotypic zidovudine-resistance mutations were maintained in the mutant virus RT genomes, and the viruses also remained phenotypically resistant to zidovudine. Given the exquisite potency of the combination of lamivudine and HBY 097 in suppressing viral replication, this combination should be further pursued in clinical trials examining treatment of HIV-1-infected persons." @default.
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- W2024661749 date "1997-11-01" @default.
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- W2024661749 title "Zidovudine‐Resistant Human Immunodeficiency Virus Type 1 Strains Subcultured in the Presence of Both Lamivudine and Quinoxaline HBY 097 Retain Marked Sensitivity to HBY 097 but Not to Lamivudine" @default.
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- W2024661749 doi "https://doi.org/10.1086/517329" @default.
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