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- W2024663750 abstract "Stimuli-responsive gels have been actively studied and applied to a variety of devices such as drug carriers, artificial muscles and actuators. In this research study, calcium alginate gels containing hydroxyapatite were prepared in one step by adding a diammonium hydrogenphosphate–1% alginate solution to a calcium chloride solution and evaluated for pH dependence and electrochemical properties as stimuli-responsive gels. When the composite gel was immersed in a solution of pH 2–10 or subjected to an applied voltage, the composite gel with a high content of hydroxyapatite tended to maintain its volume. The composite gels immersed in a pH indicator solution changed color with an applied voltage. As a result, it was revealed that alteration of the pH of composite gels occurred by electro-osmosis and electrophoresis. Swelling and shrinking of the composite gels were controlled by the external stimuli of pH, voltage and the content of hydroxyapatite; therefore, it is proposed that composite gels would be good bone-filling material having the function of drug carriers. Calcium alginate gels containing hydroxyapatite were prepared in one step and evaluated with regard to pH dependence and electrochemical property for applying to drug carriers. The composite gels immersed in a pH indicator solution changed its color by applying voltage. By these results, it was revealed that pH alteration of composite gels occurred by electro-osmosis and electrophoresis. Swelling and shrinking of the composite gels were controlled by external stimuli of pH and voltage and the content of hydroxyapatite." @default.
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- W2024663750 date "2010-01-06" @default.
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- W2024663750 title "Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels" @default.
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- W2024663750 doi "https://doi.org/10.1038/pj.2009.310" @default.
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