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- W2024664530 abstract "The effects of chronic administration of l-thyroxine on some functions of the heart in normal and myopathic Syrian hamsters (strain BIO 14.6) were investigated. In contrast to normal controls, in myopathic hamsters administration of low doses of l-thyroxine for 4 weeks failed to induce tachycardia, increase the total activity of NaK-ATPase (EC 3.6.1.3) within the cells or improve contractility of the heart muscle. In addition, l-thyroxine treatment decreased the activity of adenyl cyclase in the myopathic and that of soluble protein kinases in both normal and myopathic hearts. Some mechanism(s) that mediate the action of l-thyroxine in the myocardium therefore may be altered or deficient in this form of hereditary cardiomyopathy of the hamster." @default.
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- W2024664530 date "1979-03-01" @default.
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- W2024664530 title "Diminished effects of ?-thyroxine on some functions and enzymes of the heart in myopathic hamsters" @default.
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- W2024664530 doi "https://doi.org/10.1016/0022-2828(79)90443-7" @default.
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