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• W2024664578 abstract "Transforming growth factors (TGF-β1 and TGF-β2) are polypeptide growth factors with a wide range of effects on the growth and differentiated function of a variety of cell types. Transforming growth factors of the β class (TGF-β) are found in large quantities in bone matrix and are synthesized by osteoblasts. For these reasons, it has been suggested that TGF-β may play a major role in the regulation of bone cell metabolism. We have studied the effects of porcine TGF-β1 and the recently described porcine TGF-β2 in a mouse clonal, osteoblastlike cell line MC3T3-EI that has previously been shown to have many characteristics of osteoblasts. In serum-containing medium, TGF-β1 inhibited alkaline phosphatase activity. The inhibition of alkaline phosphatase activity persisted for at least 72 h following a brief (24 h) exposure to TGF-β1, TGF-β1 also caused a marked change in cell morphology. High doses inhibited collagen synthesis; lower concentrations caused a small increase. Under serum-free conditions, TGF-β1 had biphasic effects on alkaline phosphatase activity inhibiting at high but stimulating at low concentrations and had only a slight stimulatory effect on collagen synthesis. Under the experimental conditions used, the effects of TGF-β1 on alkaline phosphatase activity and collagen synthesis were independent of effects on cell proliferation. In serum-containing medium, TGF-β2 inhibited alkaline phosphatase activity, an effect that was independent of changes in cell proliferation and caused shape changes in an identical fashion to that observed with TGF-β1." @default.
• W2024664578 created "2016-06-24" @default.
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• W2024664578 date "2009-12-03" @default.
• W2024664578 modified "2023-09-27" @default.
• W2024664578 title "Effects of transforming growth factors β1 and β2 on a mouse clonal, osteoblastlike cell line MC3T3-E1" @default.
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• W2024664578 doi "https://doi.org/10.1002/jbmr.5650040107" @default.
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