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- W2024666478 abstract "Despite the high therapeutic potential of many macromolecular drugs, it has proven difficult to apply them to treatment of cancer and other degenerative diseases of the central nervous system (CNS) due to low capillary permeability and low diffusivity. To overcome these barriers, recent experimental studies have shown local infusion, i.e., convection-enhanced delivery (CED), to be a promising delivery technique in the brain and spinal cord [1–3]. Predictive models of extracellular fluid flow and transport during CED would be useful for treatment optimization and planning." @default.
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- W2024666478 date "2009-06-17" @default.
- W2024666478 modified "2023-09-23" @default.
- W2024666478 title "A Computational Model of Direct Infusion Into the Rat Brain: Corpus Callosum and Hippocampus" @default.
- W2024666478 doi "https://doi.org/10.1115/sbc2009-205945" @default.
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