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- W2024667221 abstract "Assess spinal reflex excitability after increasing intrathecal baclofen (ITB) flow by manipulation of drug concentration and mode of administration.The effect of concentration was assessed by comparing changes in H-reflex (H/M ratio) 1-6h after a 50μg ITB bolus at 50μg/ml concentration administered manually via lumbar puncture (LP, duration 1-2min, n=27) to a 50μg bolus at 500μg/ml concentration programmed through the pump and delivered via intrathecal catheter (IC, duration 10min) above simple continuous dose (25-100μg/day, n=16). The effect of mode of administration was assessed by comparing peak changes in H/M ratio after 50μg IC bolus above simple continuous dose (complex continuous mode, n=27) to simple continuous mode only (n=22) at equivalent daily doses (75-150μg/day).H/M decrease was faster and overall greater after LP than IC bolus (mean 1-h 77% vs. 63%, p=0.012; 1-6h 91% vs. 82%, p<0.001, respectively). H/M ratio also decreased significantly more with complex (91%) than simple continuous mode of administration (78%, p=0.025).Lower ITB concentration and complex continuous mode of administration lead to greater decrease in H/M ratio.Decreased spinal reflex excitability after adjustment of drug and pump parameters to increase ITB flow may result in better clinical response." @default.
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- W2024667221 date "2012-11-01" @default.
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- W2024667221 title "Effect of concentration and mode of intrathecal baclofen administration on soleus H-reflex in patients with muscle hypertonia" @default.
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- W2024667221 doi "https://doi.org/10.1016/j.clinph.2012.04.007" @default.
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