Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024667537> ?p ?o ?g. }
- W2024667537 endingPage "24" @default.
- W2024667537 startingPage "17" @default.
- W2024667537 abstract "We provide new viewpoints of hormonal control of benign prostatic hyperplasia (BPH). The latest treatment findings with 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride, refined indications, efficacy, and safety are discussed and compared. We also discuss potential new 5-ARIs and other hormonal treatments.Finasteride and dutasteride have equal efficacy and safety for the treatment and prevention of progression of BPH. 5-ARIs are especially recommended for prostates greater than 40 ml and PSA greater than 1.5 ng/ml. Combination therapy is the treatment of choice in these patients, but with prostate volume greater than 58 ml or International Prostate Symptom Score of at least 20, combinations have no advantage over 5-ARI monotherapy. Updates on the recent developments on BPH therapy with luteinizing hormone-releasing hormone (LHRH) antagonist are also reviewed and analyzed. Preclinical studies suggest that growth hormone-releasing hormone (GHRH) antagonists effectively shrink experimentally enlarged prostates alone or in combination with LHRH antagonists.New 5-ARIs seem to be the promising agents that need further study. Preclinical studies revealed that GHRH and LHRH antagonists both can cause a reduction in prostate volume. Recent data indicate that prostate shrinkage is induced by the direct inhibitory action of GHRH and of LHRH antagonists exerted through prostatic receptors. The adverse effects of 5ARIs encourage alternative therapy." @default.
- W2024667537 created "2016-06-24" @default.
- W2024667537 creator A5005831998 @default.
- W2024667537 creator A5007553347 @default.
- W2024667537 creator A5009332074 @default.
- W2024667537 creator A5034304928 @default.
- W2024667537 creator A5063861158 @default.
- W2024667537 creator A5064993820 @default.
- W2024667537 creator A5080485033 @default.
- W2024667537 date "2013-01-01" @default.
- W2024667537 modified "2023-09-26" @default.
- W2024667537 title "Hormonal manipulation of benign prostatic hyperplasia" @default.
- W2024667537 cites W1566339846 @default.
- W2024667537 cites W1581876684 @default.
- W2024667537 cites W1584105093 @default.
- W2024667537 cites W1681234118 @default.
- W2024667537 cites W1729580440 @default.
- W2024667537 cites W1748509901 @default.
- W2024667537 cites W1964621103 @default.
- W2024667537 cites W1965831940 @default.
- W2024667537 cites W1968446960 @default.
- W2024667537 cites W1969317618 @default.
- W2024667537 cites W1976141923 @default.
- W2024667537 cites W1979802355 @default.
- W2024667537 cites W1980931922 @default.
- W2024667537 cites W1981147501 @default.
- W2024667537 cites W1981831159 @default.
- W2024667537 cites W1989159380 @default.
- W2024667537 cites W1998301441 @default.
- W2024667537 cites W2001904774 @default.
- W2024667537 cites W2002664683 @default.
- W2024667537 cites W2003588392 @default.
- W2024667537 cites W2005687876 @default.
- W2024667537 cites W2005954857 @default.
- W2024667537 cites W2015365302 @default.
- W2024667537 cites W2021424019 @default.
- W2024667537 cites W2022147624 @default.
- W2024667537 cites W2022708876 @default.
- W2024667537 cites W2025025874 @default.
- W2024667537 cites W2057008998 @default.
- W2024667537 cites W2058048513 @default.
- W2024667537 cites W2058184287 @default.
- W2024667537 cites W2060467856 @default.
- W2024667537 cites W2063175063 @default.
- W2024667537 cites W2063530759 @default.
- W2024667537 cites W2064315968 @default.
- W2024667537 cites W2065579733 @default.
- W2024667537 cites W2066028373 @default.
- W2024667537 cites W2069432968 @default.
- W2024667537 cites W2074140598 @default.
- W2024667537 cites W2075790098 @default.
- W2024667537 cites W2079340088 @default.
- W2024667537 cites W2081597080 @default.
- W2024667537 cites W2083469330 @default.
- W2024667537 cites W2084292926 @default.
- W2024667537 cites W2085580830 @default.
- W2024667537 cites W2092585267 @default.
- W2024667537 cites W2093034620 @default.
- W2024667537 cites W2102927329 @default.
- W2024667537 cites W2106501078 @default.
- W2024667537 cites W2116466362 @default.
- W2024667537 cites W2121759271 @default.
- W2024667537 cites W2125528875 @default.
- W2024667537 cites W2130335721 @default.
- W2024667537 cites W2134130989 @default.
- W2024667537 cites W2142480001 @default.
- W2024667537 cites W2142563833 @default.
- W2024667537 cites W2155530804 @default.
- W2024667537 cites W2157715384 @default.
- W2024667537 cites W2162805000 @default.
- W2024667537 cites W2239654675 @default.
- W2024667537 cites W2318854599 @default.
- W2024667537 cites W3135529189 @default.
- W2024667537 cites W4362207783 @default.
- W2024667537 cites W65134806 @default.
- W2024667537 doi "https://doi.org/10.1097/mou.0b013e32835abd18" @default.
- W2024667537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23202285" @default.
- W2024667537 hasPublicationYear "2013" @default.
- W2024667537 type Work @default.
- W2024667537 sameAs 2024667537 @default.
- W2024667537 citedByCount "17" @default.
- W2024667537 countsByYear W20246675372013 @default.
- W2024667537 countsByYear W20246675372014 @default.
- W2024667537 countsByYear W20246675372015 @default.
- W2024667537 countsByYear W20246675372016 @default.
- W2024667537 countsByYear W20246675372017 @default.
- W2024667537 countsByYear W20246675372018 @default.
- W2024667537 countsByYear W20246675372019 @default.
- W2024667537 countsByYear W20246675372020 @default.
- W2024667537 crossrefType "journal-article" @default.
- W2024667537 hasAuthorship W2024667537A5005831998 @default.
- W2024667537 hasAuthorship W2024667537A5007553347 @default.
- W2024667537 hasAuthorship W2024667537A5009332074 @default.
- W2024667537 hasAuthorship W2024667537A5034304928 @default.
- W2024667537 hasAuthorship W2024667537A5063861158 @default.
- W2024667537 hasAuthorship W2024667537A5064993820 @default.
- W2024667537 hasAuthorship W2024667537A5080485033 @default.
- W2024667537 hasBestOaLocation W20246675371 @default.