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• W2024668216 endingPage "4375" @default.
• W2024668216 startingPage "4365" @default.
• W2024668216 abstract "Recent work in our laboratory shows that it is possible to reproducibly measure the weight change over time of a piece of porcine skin exposed to a chemical vapor by thermogravimetric analysis (TGA), that is, using a microbalance maintained at constant temperature and humidity. Here, we develop a diffusion model by which the TGA skin weight curve can be interpreted. A TGA-specific analytical solution for Fick's second law of diffusion was derived. The solution contains two chemical-dependent parameters; a diffusion coefficient (D) and a skin/air partition coefficient (P). The resulting function was fitted to weight curves from 83 experiments with 4 chemicals; n-butyl acetate, methanol, 2-propanol, and toluene. In most experiments, a single weight function could not adequately describe the shape of the weight curve, therefore up to five parallel compartments, each with its parameter set Di and Pi, were tested. A two-compartment model was adequate for 58% of the experiments according to the Akaike Information Criterion. Dermal penetration of the chemicals was also measured with Franz diffusion cells. The diffusion coefficients obtained by the two methods agreed well. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4365–4375, 2009" @default.
• W2024668216 created "2016-06-24" @default.
• W2024668216 creator A5055249382 @default.
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• W2024668216 date "2009-11-01" @default.
• W2024668216 modified "2023-10-18" @default.
• W2024668216 title "Assessment of dermal absorption by thermogravimetric analysis: Development of a diffusion model based on Fick's second law" @default.
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• W2024668216 doi "https://doi.org/10.1002/jps.21709" @default.
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