FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024669394> ?p ?o ?g. }

• W2024669394 endingPage "10540" @default.
• W2024669394 startingPage "10536" @default.
• W2024669394 abstract "Three distinct genes encoding members of the D1 dopamine receptor family were isolated from Xenopus laevis. Based on the deduced amino acid sequence, two of the receptors (Xen D1A and Xen D1B) appear to be homologues of mammalian D1/D1A and D5/D1B receptors. The third receptor, termed Xen D1C, displays equal overall amino acid and nucleotide sequence identity (approximately 55%) with mammalian D1A and D1B/D5 receptors. In agreement with their structural similarities, Xen D1A and D1B receptors, when expressed in COS-7 cells, displayed pharmacological profiles that paralleled those of their mammalian counterparts, with dopamine and 2-amino-6,7-dihydroxytetralin exhibiting 10-fold higher affinity for D1B than for D1A. The Xen D1C receptor displayed an overall rank order of potency and pharmacological profile clearly indicative of a D1-like receptor, with individual affinities for most agonists higher than those for either Xen or mammalian D1/D1A and D5/D1B receptors, whereas antagonist Ki values were intermediate to those for the D1/D1A and D5/D1B receptors. All three receptors stimulated adenylate cyclase activity in response to dopamine or SKF-82526. Xen D1A, D1B, and D1C receptor mRNAs were differentially distributed, with all three receptors expressed in brain and only D1B and D1C receptors expressed in kidney. The existence of a receptor which lacks appreciable overall sequence similarity to, but displays pharmacological homology with, mammalian D1-like receptors lends strong support to the contention that additional mammalian D1-like receptor gene products may exist to allow for the expression of the full spectrum of D1-like dopamine receptor-mediated events." @default.
• W2024669394 created "2016-06-24" @default.
• W2024669394 creator A5008230738 @default.
• W2024669394 creator A5022008748 @default.
• W2024669394 creator A5054347925 @default.
• W2024669394 creator A5084826064 @default.
• W2024669394 date "1994-10-25" @default.
• W2024669394 modified "2023-10-16" @default.
• W2024669394 title "D1A, D1B, and D1C dopamine receptors from Xenopus laevis." @default.
• W2024669394 cites W1498373517 @default.
• W2024669394 cites W1506108353 @default.
• W2024669394 cites W1547923480 @default.
• W2024669394 cites W1580174349 @default.
• W2024669394 cites W1580341418 @default.
• W2024669394 cites W1601345792 @default.
• W2024669394 cites W1925289812 @default.
• W2024669394 cites W1927946021 @default.
• W2024669394 cites W1970843048 @default.
• W2024669394 cites W1971417227 @default.
• W2024669394 cites W1979027736 @default.
• W2024669394 cites W1994353461 @default.
• W2024669394 cites W1994518490 @default.
• W2024669394 cites W2001566515 @default.
• W2024669394 cites W2005400238 @default.
• W2024669394 cites W2009355260 @default.
• W2024669394 cites W2009578696 @default.
• W2024669394 cites W2015907077 @default.
• W2024669394 cites W2017549779 @default.
• W2024669394 cites W2020164902 @default.
• W2024669394 cites W2030905853 @default.
• W2024669394 cites W2040777203 @default.
• W2024669394 cites W2040883320 @default.
• W2024669394 cites W2043001547 @default.
• W2024669394 cites W2048770548 @default.
• W2024669394 cites W206085204 @default.
• W2024669394 cites W2066097401 @default.
• W2024669394 cites W2067028469 @default.
• W2024669394 cites W2075926563 @default.
• W2024669394 cites W2076668798 @default.
• W2024669394 cites W2084530213 @default.
• W2024669394 cites W2087688448 @default.
• W2024669394 cites W2090565260 @default.
• W2024669394 cites W2095782370 @default.
• W2024669394 cites W2102541501 @default.
• W2024669394 cites W2154128645 @default.
• W2024669394 cites W2402489441 @default.
• W2024669394 cites W2417234489 @default.
• W2024669394 cites W2419256972 @default.
• W2024669394 cites W2425074573 @default.
• W2024669394 cites W2428648575 @default.
• W2024669394 cites W245031103 @default.
• W2024669394 cites W4231195547 @default.
• W2024669394 doi "https://doi.org/10.1073/pnas.91.22.10536" @default.
• W2024669394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/45056" @default.
• W2024669394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7937989" @default.
• W2024669394 hasPublicationYear "1994" @default.
• W2024669394 type Work @default.
• W2024669394 sameAs 2024669394 @default.
• W2024669394 citedByCount "59" @default.
• W2024669394 countsByYear W20246693942012 @default.
• W2024669394 countsByYear W20246693942014 @default.
• W2024669394 countsByYear W20246693942015 @default.
• W2024669394 countsByYear W20246693942020 @default.
• W2024669394 countsByYear W20246693942021 @default.
• W2024669394 countsByYear W20246693942022 @default.
• W2024669394 countsByYear W20246693942023 @default.
• W2024669394 crossrefType "journal-article" @default.
• W2024669394 hasAuthorship W2024669394A5008230738 @default.
• W2024669394 hasAuthorship W2024669394A5022008748 @default.
• W2024669394 hasAuthorship W2024669394A5054347925 @default.
• W2024669394 hasAuthorship W2024669394A5084826064 @default.
• W2024669394 hasBestOaLocation W20246693941 @default.
• W2024669394 hasConcept C104317684 @default.
• W2024669394 hasConcept C120069818 @default.
• W2024669394 hasConcept C120750228 @default.
• W2024669394 hasConcept C135285700 @default.
• W2024669394 hasConcept C141961939 @default.
• W2024669394 hasConcept C14200731 @default.
• W2024669394 hasConcept C170493617 @default.
• W2024669394 hasConcept C2779535977 @default.
• W2024669394 hasConcept C55493867 @default.
• W2024669394 hasConcept C86803240 @default.
• W2024669394 hasConcept C95444343 @default.
• W2024669394 hasConceptScore W2024669394C104317684 @default.
• W2024669394 hasConceptScore W2024669394C120069818 @default.
• W2024669394 hasConceptScore W2024669394C120750228 @default.
• W2024669394 hasConceptScore W2024669394C135285700 @default.
• W2024669394 hasConceptScore W2024669394C141961939 @default.
• W2024669394 hasConceptScore W2024669394C14200731 @default.
• W2024669394 hasConceptScore W2024669394C170493617 @default.
• W2024669394 hasConceptScore W2024669394C2779535977 @default.
• W2024669394 hasConceptScore W2024669394C55493867 @default.
• W2024669394 hasConceptScore W2024669394C86803240 @default.
• W2024669394 hasConceptScore W2024669394C95444343 @default.
• W2024669394 hasIssue "22" @default.
• W2024669394 hasLocation W20246693941 @default.
• W2024669394 hasLocation W20246693942 @default.
• W2024669394 hasLocation W20246693943 @default.

• next