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- W2024672076 endingPage "321" @default.
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- W2024672076 abstract "The present paper reviews the currently available in vivo systems for detection of chemically induced mutations and chromosome aberrations and summarizes the data of the relevant tests for mammalian germ-cell mutations (specific-locus test and heritable translocation test). The value of in vivo screening tests (somatic mutations and sperm abnormalities) for predicting specific-locus mutations is illustrated by comparing doubling doses. The results from the mammalian germ-cell mutation tests (specific-locus test and heritable translocation test) constitute the base-line for an assessment of predictability. Radiation and chemically induced specific-locus mutations differ in a number of respects, suggesting a need for caution in making risk estimates for chemical mutagen exposures in terms of radiation-equivalent doses. In vivo nondisjunction tests are discussed. Finally, unsolved problems and difficulties in generalizing qualitative and quantitative correlations between test systems are outlined. It is concluded that even qualitative predictions from data on somatic cells to germ cells are at best insecure because germ-cell specificity cannot be foretold, not to mention the fact that quantitative extrapolations from the results of in vivo screening tests, in general, are fraught with even more uncertainties. There is an acute need for collection of more data from studies involving germ cells." @default.
- W2024672076 created "2016-06-24" @default.
- W2024672076 creator A5027059438 @default.
- W2024672076 date "1983-08-01" @default.
- W2024672076 modified "2023-09-25" @default.
- W2024672076 title "Comparison of types of chemically induced genetic changes in mammals" @default.
- W2024672076 cites W134903604 @default.
- W2024672076 cites W1514983379 @default.
- W2024672076 cites W1530988701 @default.
- W2024672076 cites W1549128156 @default.
- W2024672076 cites W1553430971 @default.
- W2024672076 cites W1750676063 @default.
- W2024672076 cites W180290601 @default.
- W2024672076 cites W1965400424 @default.
- W2024672076 cites W1965831140 @default.
- W2024672076 cites W1965947476 @default.
- W2024672076 cites W1965966508 @default.
- W2024672076 cites W1967420611 @default.
- W2024672076 cites W1968988867 @default.
- W2024672076 cites W1970651721 @default.
- W2024672076 cites W1970878356 @default.
- W2024672076 cites W1972270911 @default.
- W2024672076 cites W1977328791 @default.
- W2024672076 cites W1980703260 @default.
- W2024672076 cites W1981060070 @default.
- W2024672076 cites W1981454187 @default.
- W2024672076 cites W1982638937 @default.
- W2024672076 cites W1984398287 @default.
- W2024672076 cites W1984685528 @default.
- W2024672076 cites W1986899024 @default.
- W2024672076 cites W1986986078 @default.
- W2024672076 cites W1989229340 @default.
- W2024672076 cites W1989776807 @default.
- W2024672076 cites W1990735394 @default.
- W2024672076 cites W1992195324 @default.
- W2024672076 cites W1996837606 @default.
- W2024672076 cites W1997663689 @default.
- W2024672076 cites W2000043840 @default.
- W2024672076 cites W2006386399 @default.
- W2024672076 cites W2008571309 @default.
- W2024672076 cites W2009299393 @default.
- W2024672076 cites W2012012919 @default.
- W2024672076 cites W2014586996 @default.
- W2024672076 cites W2014617952 @default.
- W2024672076 cites W2018437991 @default.
- W2024672076 cites W2018696101 @default.
- W2024672076 cites W2019256883 @default.
- W2024672076 cites W2019318714 @default.
- W2024672076 cites W2020510824 @default.
- W2024672076 cites W2023098203 @default.
- W2024672076 cites W2024606050 @default.
- W2024672076 cites W2024877354 @default.
- W2024672076 cites W2029421106 @default.
- W2024672076 cites W2030172687 @default.
- W2024672076 cites W2030436257 @default.
- W2024672076 cites W2038303058 @default.
- W2024672076 cites W2039326534 @default.
- W2024672076 cites W2042280131 @default.
- W2024672076 cites W2047444189 @default.
- W2024672076 cites W2048350441 @default.
- W2024672076 cites W2049971638 @default.
- W2024672076 cites W2051747581 @default.
- W2024672076 cites W2057489950 @default.
- W2024672076 cites W2062612735 @default.
- W2024672076 cites W2063087419 @default.
- W2024672076 cites W2063620930 @default.
- W2024672076 cites W2065229809 @default.
- W2024672076 cites W2067653526 @default.
- W2024672076 cites W2072054233 @default.
- W2024672076 cites W2073555391 @default.
- W2024672076 cites W2074300869 @default.
- W2024672076 cites W2076114052 @default.
- W2024672076 cites W2076511356 @default.
- W2024672076 cites W2081027237 @default.
- W2024672076 cites W2081161641 @default.
- W2024672076 cites W2082947321 @default.
- W2024672076 cites W2083215512 @default.
- W2024672076 cites W2086616789 @default.
- W2024672076 cites W2086878233 @default.
- W2024672076 cites W2087509014 @default.
- W2024672076 cites W2089254958 @default.
- W2024672076 cites W2090213597 @default.
- W2024672076 cites W2090906476 @default.
- W2024672076 cites W2091513630 @default.
- W2024672076 cites W2093675256 @default.
- W2024672076 cites W2097155138 @default.
- W2024672076 cites W2101441104 @default.
- W2024672076 cites W2105629018 @default.
- W2024672076 cites W2114192043 @default.
- W2024672076 cites W2123734454 @default.
- W2024672076 cites W2127420510 @default.
- W2024672076 cites W2142102875 @default.
- W2024672076 cites W2154857285 @default.
- W2024672076 cites W2202150090 @default.
- W2024672076 cites W2313940249 @default.
- W2024672076 cites W2320465545 @default.
- W2024672076 cites W2725134764 @default.
- W2024672076 cites W2911778945 @default.